TY - JOUR
T1 - Water Soluble Luminescent Cyclometalated Platinum(Ii) Complex — a Suitable Probe for Bio-Imaging Applications
AU - Pasha, Saleem
AU - Das, Pradip
AU - Rath, Nigam P.
AU - Bandyopadhyay, Debashree
AU - Jana, Nikhil R.
AU - Laskar, Inamur Rahaman
N1 - A highly water soluble platinum(II) complex, [Pt(ppy)(en)]Cl, (where ppy=2-phenylpyridine and en=ethane-1, 2-diamine) with a strong green luminescence...
PY - 2016/5/1
Y1 - 2016/5/1
N2 - A highly water soluble platinum(II) complex, [Pt(ppy)(en)]Cl, (where ppy = 2-phenylpyridine and en = ethane-1, 2-diamine) with a strong green luminescence in solution was synthesized in two steps. Initially, an intermediate complex, [Pt(ppy)(ppyH)(Cl)], 1 was isolated which was transformed into the light-emitting mononuclear platinum(II) complex, [Pt(ppy)(en)]Cl, 2. The green emission of 2 was changed into yellow in their solid state. The strong π … π intermolecular interactions that interplays between the phenyl rings lying into the two consecutive molecules which led to the solid state emission. The low cytotoxicity of 2 ensures the feasibility for using these in bioimaging probe. The testing bioimaging results demonstrate that the compound penetrates the cell membrane in both cancer (HeLa, U87MG and Nuro2a) and normal cells (CHO-K1 and 3T3-L1). The cellular uptake was observed to much higher in cancerous cells only. Co-localization study confirmed the localization of it into the cell nucleus.
AB - A highly water soluble platinum(II) complex, [Pt(ppy)(en)]Cl, (where ppy = 2-phenylpyridine and en = ethane-1, 2-diamine) with a strong green luminescence in solution was synthesized in two steps. Initially, an intermediate complex, [Pt(ppy)(ppyH)(Cl)], 1 was isolated which was transformed into the light-emitting mononuclear platinum(II) complex, [Pt(ppy)(en)]Cl, 2. The green emission of 2 was changed into yellow in their solid state. The strong π … π intermolecular interactions that interplays between the phenyl rings lying into the two consecutive molecules which led to the solid state emission. The low cytotoxicity of 2 ensures the feasibility for using these in bioimaging probe. The testing bioimaging results demonstrate that the compound penetrates the cell membrane in both cancer (HeLa, U87MG and Nuro2a) and normal cells (CHO-K1 and 3T3-L1). The cellular uptake was observed to much higher in cancerous cells only. Co-localization study confirmed the localization of it into the cell nucleus.
KW - platinum complex
KW - bio-imaging
KW - luminescence
KW - toxicity
UR - https://www.sciencedirect.com/science/article/pii/S1387700316300806
UR - https://doi.org/10.1016/j.inoche.2016.03.017
U2 - 10.1016/j.inoche.2016.03.017
DO - 10.1016/j.inoche.2016.03.017
M3 - Article
VL - 67
JO - Inorganic Chemistry Communications
JF - Inorganic Chemistry Communications
ER -