Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging

Lauren E. Salminen; Peter R. Schofield; Peter R. Schofield; Kerrie D. Pierce; Steven E. Bruce; Michael G. Griffin; David F. Tate; Ryan P. Cabeen; David H. Laidlaw; Thomas E. Conturo; Jacob D. Bolzenius; Robert H. Paul; Robert H. Paul

doi:10.1016/j.bbr.2017.04.041

Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging

Lauren E. Salminen, Peter R. Schofield, Peter R. Schofield, Kerrie D. Pierce, Steven E. Bruce, Michael G. Griffin, David F. Tate, Ryan P. Cabeen, David H. Laidlaw, Thomas E. Conturo, Jacob D. Bolzenius, Robert H. Paul, Robert H. Paul

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 ( SOD2) and catalase (CAT ) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.

Original language	American English
Journal	Behavioural Brain Research
Volume	329
DOIs	https://doi.org/10.1016/j.bbr.2017.04.041
State	Published - Jun 1 2017

Keywords

Brain aging
Oxidative stress
SOD2
Catalase
White matter
Cognition

Disciplines

Endocrinology
Biology
Developmental Psychology
Internal Medicine

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Salminen, L. E., Schofield, P. R., Schofield, P. R., Pierce, K. D., Bruce, S. E., Griffin, M. G., Tate, D. F., Cabeen, R. P., Laidlaw, D. H., Conturo, T. E., Bolzenius, J. D., Paul, R. H., & Paul, R. H. (2017). Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging. Behavioural Brain Research, 329. https://doi.org/10.1016/j.bbr.2017.04.041

Salminen, LE, Schofield, PR, Schofield, PR, Pierce, KD, Bruce, SE , Griffin, MG, Tate, DF, Cabeen, RP, Laidlaw, DH, Conturo, TE, Bolzenius, JD, Paul, RH & Paul, RH 2017, 'Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging', Behavioural Brain Research, vol. 329. https://doi.org/10.1016/j.bbr.2017.04.041

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title = "Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging",

abstract = " Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 ( SOD2) and catalase (CAT ) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals. ",

keywords = "Brain aging, Oxidative stress, SOD2, Catalase, White matter, Cognition",

author = "Salminen, {Lauren E.} and Schofield, {Peter R.} and Schofield, {Peter R.} and Pierce, {Kerrie D.} and Bruce, {Steven E.} and Griffin, {Michael G.} and Tate, {David F.} and Cabeen, {Ryan P.} and Laidlaw, {David H.} and Conturo, {Thomas E.} and Bolzenius, {Jacob D.} and Paul, {Robert H.} and Paul, {Robert H.}",

note = "JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. * The SOD2/rs4880 SNP is associated with white matter abnormalities in older adults. * The anterior thalamic radiation is vulnerable to aging in CC genotypes of SOD2.",

year = "2017",

month = jun,

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doi = "10.1016/j.bbr.2017.04.041",

language = "American English",

volume = "329",

journal = "Behavioural Brain Research",

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TY - JOUR

T1 - Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging

AU - Salminen, Lauren E.

AU - Schofield, Peter R.

AU - Pierce, Kerrie D.

AU - Bruce, Steven E.

AU - Griffin, Michael G.

AU - Tate, David F.

AU - Cabeen, Ryan P.

AU - Laidlaw, David H.

AU - Conturo, Thomas E.

AU - Bolzenius, Jacob D.

AU - Paul, Robert H.

N1 - JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. * The SOD2/rs4880 SNP is associated with white matter abnormalities in older adults. * The anterior thalamic radiation is vulnerable to aging in CC genotypes of SOD2.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 ( SOD2) and catalase (CAT ) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.

AB - Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 ( SOD2) and catalase (CAT ) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.

KW - Brain aging

KW - Oxidative stress

KW - SOD2

KW - Catalase

KW - White matter

KW - Cognition

UR - https://www.sciencedirect.com/science/article/pii/S0166432817304837

U2 - 10.1016/j.bbr.2017.04.041

DO - 10.1016/j.bbr.2017.04.041

M3 - Article

VL - 329

JO - Behavioural Brain Research

JF - Behavioural Brain Research

ER -

Vulnerability of White Matter Tracts and Cognition to the SOD2 Polymorphism: A Preliminary Study of Antioxidant Defense Genes in Brain Aging

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