The preparation and reactions of chiral phosphorous acid diamides

Kevin J. Koeller; Christopher Spilling

doi:10.1016/0040-4039(91)80151-U

The preparation and reactions of chiral phosphorous acid diamides

Kevin J. Koeller, Christopher Spilling

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

Chiral phosphorous acid diamides were prepared by condensation of N,N′-disubstituted C 2 diamines with PCl 3 followed by an equivalent of water. Deprotonation of these acids with n-butyl lithium or LDA gave the lithium salt which reacted smoothly with alkyl halides to give the substituted phosphonamides in good yield.

Original language	American English
Journal	Tetrahedron Letters
Volume	32
DOIs	https://doi.org/10.1016/0040-4039(91)80151-U
State	Published - Oct 1991

Disciplines

Physical Sciences and Mathematics
Chemistry
Organic Chemistry

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title = "The preparation and reactions of chiral phosphorous acid diamides",

abstract = " Chiral phosphorous acid diamides were prepared by condensation of N,N′-disubstituted C 2 diamines with PCl 3 followed by an equivalent of water. Deprotonation of these acids with n-butyl lithium or LDA gave the lithium salt which reacted smoothly with alkyl halides to give the substituted phosphonamides in good yield.",

author = "Koeller, {Kevin J.} and Christopher Spilling",

note = "Chiral phosphorous acid diamides were prepared by condensation of N,N′-disubstituted C2 diamines with PCl3 followed by an equivalent of water. Deproto...",

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doi = "10.1016/0040-4039(91)80151-U",

language = "American English",

volume = "32",

journal = "Tetrahedron Letters",

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T1 - The preparation and reactions of chiral phosphorous acid diamides

AU - Koeller, Kevin J.

AU - Spilling, Christopher

N1 - Chiral phosphorous acid diamides were prepared by condensation of N,N′-disubstituted C2 diamines with PCl3 followed by an equivalent of water. Deproto...

PY - 1991/10

Y1 - 1991/10

N2 - Chiral phosphorous acid diamides were prepared by condensation of N,N′-disubstituted C 2 diamines with PCl 3 followed by an equivalent of water. Deprotonation of these acids with n-butyl lithium or LDA gave the lithium salt which reacted smoothly with alkyl halides to give the substituted phosphonamides in good yield.

AB - Chiral phosphorous acid diamides were prepared by condensation of N,N′-disubstituted C 2 diamines with PCl 3 followed by an equivalent of water. Deprotonation of these acids with n-butyl lithium or LDA gave the lithium salt which reacted smoothly with alkyl halides to give the substituted phosphonamides in good yield.

UR - https://www.sciencedirect.com/science/article/abs/pii/004040399180151U

U2 - 10.1016/0040-4039(91)80151-U

DO - 10.1016/0040-4039(91)80151-U

M3 - Article

VL - 32

JO - Tetrahedron Letters

JF - Tetrahedron Letters

ER -

The preparation and reactions of chiral phosphorous acid diamides

Abstract

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