The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Galβ1→3GlcNAcβ1→3Galβ1→4Glc)

Mithila D. Bandara, Keith Stine, Alexei V. Demchenko

Research output: Contribution to journalArticlepeer-review

Abstract

The total chemical synthesis of lacto- N -tetraose (LNT) has been completed using both convergent and linear strategies. Similarly to that of our previous HMO syntheses, the donor-acceptor protecting-leaving group combinations were found to be of paramount significance to achieving successful glycosylations and minimizing side reactions.
Original languageAmerican English
JournalCarbohydrate Research
Volume486
DOIs
StatePublished - Sep 22 2019

Disciplines

  • Life Sciences
  • Biochemistry, Biophysics, and Structural Biology
  • Biochemistry
  • Medical Biochemistry
  • Biology
  • Organic Chemistry

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