TY - JOUR
T1 - Synthesis, X-ray crystal structure, DNA binding, antioxidant and cytotoxicity studies of Ni(ii) and Pd(ii) thiosemicarbazone complexes
AU - Ramachandran, Eswaran
AU - Kalainani, Palaniappan
AU - Prabhakaran, Rapinasabapathi
AU - Rath, Nigam
AU - Brinda, Selvaraj
AU - Poornima, Paramasivan
AU - Padma, Viswanatha V
AU - Natarajan, Karuppannan
N1 - New complexes, [Ni(HL)(PPh)]Cl ( 1), [Pd(L)(PPh)]( 2), and [Pd(L)(AsPh)]( 3), were synthesized from the reactions of 4-chloro-5-methyl-salicylaldehyde thiosemicarbazone [HL] with [NiCl(PPh)], [PdCl(PPh)] and [PdCl(AsPh)]. They were characterized by IR, electronic, spectral data. Further, the structures of the complexes have been determined by single crystal X-ray diffraction.
PY - 2011/11/21
Y1 - 2011/11/21
N2 - New complexes, [Ni(HL)(PPh 3 )]Cl (1), [Pd(L)(PPh 3 )](2), and [Pd(L)(AsPh 3 )](3), were synthesized from the reactions of 4-chloro-5-methyl-salicylaldehyde thiosemicarbazone [H 2 L] with [NiCl 2 (PPh 3 ) 2 ], [PdCl 2 (PPh 3 ) 2 ] and [PdCl 2 (AsPh 3 ) 2 ]. They were characterized by IR, electronic, 1H-NMR spectral data. Further, the structures of the complexes have been determined by single crystal X-ray diffraction. While the thiosemicarbazone coordinated as binegative tridentate (ONS) in complexes 2 and 3, it is coordinated as mono negative tridentate (ONS) in 1. The interactions of the new complexes with calf thymus DNA was examined by absorption and emission spectra, and viscosity measurements. Moreover, the antioxidant properties of the new complexes have also been tested against DPPH radical in which complex 1 exhibited better activity than that of the other two complexes 2 and 3. The in vitro cytotoxicity of complexes 1–3 against A549 and HepG2 cell lines was assayed, and the new complexes exhibited higher cytotoxic activity with lower IC 50 values indicating their efficiency in killing the cancer cells even at very low concentrations.
AB - New complexes, [Ni(HL)(PPh 3 )]Cl (1), [Pd(L)(PPh 3 )](2), and [Pd(L)(AsPh 3 )](3), were synthesized from the reactions of 4-chloro-5-methyl-salicylaldehyde thiosemicarbazone [H 2 L] with [NiCl 2 (PPh 3 ) 2 ], [PdCl 2 (PPh 3 ) 2 ] and [PdCl 2 (AsPh 3 ) 2 ]. They were characterized by IR, electronic, 1H-NMR spectral data. Further, the structures of the complexes have been determined by single crystal X-ray diffraction. While the thiosemicarbazone coordinated as binegative tridentate (ONS) in complexes 2 and 3, it is coordinated as mono negative tridentate (ONS) in 1. The interactions of the new complexes with calf thymus DNA was examined by absorption and emission spectra, and viscosity measurements. Moreover, the antioxidant properties of the new complexes have also been tested against DPPH radical in which complex 1 exhibited better activity than that of the other two complexes 2 and 3. The in vitro cytotoxicity of complexes 1–3 against A549 and HepG2 cell lines was assayed, and the new complexes exhibited higher cytotoxic activity with lower IC 50 values indicating their efficiency in killing the cancer cells even at very low concentrations.
UR - https://doi.org/10.1039/C1MT00143D
U2 - 10.1039/C1MT00143D
DO - 10.1039/C1MT00143D
M3 - Article
VL - 4
JO - Metallomics
JF - Metallomics
ER -