Structure-based Parallel Medicinal Chemistry Approach to Improve Metabolic Stability of Benzopyran COX-2 Inhibitors

Li Xing; Bruce C. Hamper; Theresa R. Fletcher; Jay M. Wendling; Jeffery Carter; James K. Gierse; Subo Liao

doi:10.1016/j.bmcl.2010.12.023

Structure-based Parallel Medicinal Chemistry Approach to Improve Metabolic Stability of Benzopyran COX-2 Inhibitors

Li Xing, Bruce C. Hamper, Theresa R. Fletcher, Jay M. Wendling, Jeffery Carter, James K. Gierse, Subo Liao

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	21
DOIs	https://doi.org/10.1016/j.bmcl.2010.12.023
State	Published - Feb 1 2011
Externally published	Yes

Disciplines

Organic Chemistry
Biochemistry
Medicinal-Pharmaceutical Chemistry

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Cite this

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title = "Structure-based Parallel Medicinal Chemistry Approach to Improve Metabolic Stability of Benzopyran COX-2 Inhibitors",

author = "Li Xing and Hamper, {Bruce C.} and Fletcher, {Theresa R.} and Wendling, {Jay M.} and Jeffery Carter and Gierse, {James K.} and Subo Liao",

note = "Combination of the structure-based design and solid-phase parallel synthesis provided an integrated approach to rapidly develop the structure-activity...",

year = "2011",

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doi = "10.1016/j.bmcl.2010.12.023",

language = "American English",

volume = "21",

journal = "Bioorganic & Medicinal Chemistry Letters",

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T1 - Structure-based Parallel Medicinal Chemistry Approach to Improve Metabolic Stability of Benzopyran COX-2 Inhibitors

AU - Xing, Li

AU - Hamper, Bruce C.

AU - Fletcher, Theresa R.

AU - Wendling, Jay M.

AU - Carter, Jeffery

AU - Gierse, James K.

AU - Liao, Subo

N1 - Combination of the structure-based design and solid-phase parallel synthesis provided an integrated approach to rapidly develop the structure-activity...

PY - 2011/2/1

Y1 - 2011/2/1

UR - https://www.sciencedirect.com/science/article/pii/S0960894X10017774

U2 - 10.1016/j.bmcl.2010.12.023

DO - 10.1016/j.bmcl.2010.12.023

M3 - Article

VL - 21

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

ER -

Structure-based Parallel Medicinal Chemistry Approach to Improve Metabolic Stability of Benzopyran COX-2 Inhibitors

Disciplines

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