Structure-Activity Relationships, Kinetics, Selectivity, and Mechanistic Studies of Synthetic Hydraphile Channels in Bacterial and Mammalian Cells

W. Matthew Leevy; Seth T. Gammon; Tatiana Levchenko; David D. Daranciang; Oscar Murillo; Vladimir Torchilin; David Piwnica-Worms; James E. Huettner; George W. Gokel; George W. Gokel

doi:10.1039/b508157b

Structure-Activity Relationships, Kinetics, Selectivity, and Mechanistic Studies of Synthetic Hydraphile Channels in Bacterial and Mammalian Cells

W. Matthew Leevy, Seth T. Gammon, Tatiana Levchenko, David D. Daranciang, Oscar Murillo, Vladimir Torchilin, David Piwnica-Worms, James E. Huettner, George W. Gokel, George W. Gokel

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Organic and Biomolecular Chemistry
Volume	3
DOIs	https://doi.org/10.1039/b508157b
State	Published - Jan 1 2005
Externally published	Yes

Disciplines

Bacteria
Cell Biology
Biology
Organic Chemistry
Toxicology

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10.1039/b508157bLicense: Unspecified

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Leevy, W. M., Gammon, S. T., Levchenko, T., Daranciang, D. D., Murillo, O., Torchilin, V., Piwnica-Worms, D., Huettner, J. E., Gokel, G. W., & Gokel, G. W. (2005). Structure-Activity Relationships, Kinetics, Selectivity, and Mechanistic Studies of Synthetic Hydraphile Channels in Bacterial and Mammalian Cells. Organic and Biomolecular Chemistry, 3. https://doi.org/10.1039/b508157b

@article{4e8b12aa1320467784c2bf944907cbbf,

title = "Structure-Activity Relationships, Kinetics, Selectivity, and Mechanistic Studies of Synthetic Hydraphile Channels in Bacterial and Mammalian Cells",

author = "Leevy, \{W. Matthew\} and Gammon, \{Seth T.\} and Tatiana Levchenko and Daranciang, \{David D.\} and Oscar Murillo and Vladimir Torchilin and David Piwnica-Worms and Huettner, \{James E.\} and Gokel, \{George W.\} and Gokel, \{George W.\}",

note = "Hydraphile compounds are shown to be cytotoxic to Gram-negative and Gram-positive bacteria, yeast, and mammalian cells. Their cellular toxicity compares favorably with other synthetic ionophores and rivals that potency of natural antibiotics. The effects of structural variations on toxicity are described. The effects of these variations correlate well with previous studies of ion transport in liposomes.",

year = "2005",

month = jan,

day = "1",

doi = "10.1039/b508157b",

language = "American English",

volume = "3",

journal = "Organic and Biomolecular Chemistry",

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TY - JOUR

T1 - Structure-Activity Relationships, Kinetics, Selectivity, and Mechanistic Studies of Synthetic Hydraphile Channels in Bacterial and Mammalian Cells

AU - Leevy, W. Matthew

AU - Gammon, Seth T.

AU - Levchenko, Tatiana

AU - Daranciang, David D.

AU - Murillo, Oscar

AU - Torchilin, Vladimir

AU - Piwnica-Worms, David

AU - Huettner, James E.

AU - Gokel, George W.

N1 - Hydraphile compounds are shown to be cytotoxic to Gram-negative and Gram-positive bacteria, yeast, and mammalian cells. Their cellular toxicity compares favorably with other synthetic ionophores and rivals that potency of natural antibiotics. The effects of structural variations on toxicity are described. The effects of these variations correlate well with previous studies of ion transport in liposomes.

PY - 2005/1/1

Y1 - 2005/1/1

UR - https://mdanderson.elsevierpure.com/en/publications/structure-activity-relationships-kinetics-selectivity-and-mechani

U2 - 10.1039/b508157b

DO - 10.1039/b508157b

M3 - Article

VL - 3

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

ER -

Structure-Activity Relationships, Kinetics, Selectivity, and Mechanistic Studies of Synthetic Hydraphile Channels in Bacterial and Mammalian Cells

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