Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study

Jutta Joormann; Samuel A. McLean; Francesca L. Beaudoin; Xinming Huang; Jennifer Stevens; Donglin Zeng; Thomas C Neylan; Gari D Clifford; Sarah D. Linnstaedt; Laura T. Germine; Scott L. Rauch; Paul I. Musey; Phyllis L. Hendry; Sophia Sheikh; Christopher W. Jones; Brittany E. Punches; Gregory J. Fermann; Lauren A. Hudak; Kamran Mohiuddin; T. VISHNU MURTY; Meghan E. McGrath; John P. Haran; Jose L Pascual; Mark Seamon; David A. Peak; Claire Pearson; Robert M. Domeier; Paulina Sergot; Roland C. Merchant; Leon D. Sanchez; Niels K. Rathlev; William F. Peacock; Steven Bruce; Deanna M Barch; Diego A. Pizzagalli; Beatriz Luna; Steven E. Harte; Irving Hwang; Sue Lee; Nancy A. Sampson; Karestan C. Koenen; Kerry J. Ressler; Ronald C. Kessler

doi:10.1017/S0033291720003773

Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study

Jutta Joormann, Samuel A. McLean, Francesca L. Beaudoin, Xinming Huang, Jennifer Stevens, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Gregory J. Fermann, Lauren A. Hudak, Kamran Mohiuddin, T. VISHNU MURTYMeghan E. McGrath, John P. Haran, Jose L Pascual, Mark Seamon, David A. Peak, Claire Pearson, Robert M. Domeier, Paulina Sergot, Roland C. Merchant, Leon D. Sanchez, Niels K. Rathlev, William F. Peacock, Steven Bruce, Deanna M Barch, Diego A. Pizzagalli, Beatriz Luna, Steven E. Harte, Irving Hwang, Sue Lee, Nancy A. Sampson, Karestan C. Koenen, Kerry J. Ressler, Ronald C. Kessler

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

   Background 
 This is the first report on the association between trauma exposure and depression from the    A  dvancing    U  nderstanding of    R  ec   O  very afte   R   traum   A  (AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience.
   Methods 
 We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression.
   Results 
 Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger    v.   driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma.
   Conclusions 
 These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.
 
 

Original language	American English
Journal	Psychological Medicine
DOIs	https://doi.org/10.1017/S0033291720003773
State	Published - 2020

Keywords

Anxiety
PTSD
depression
trauma

Disciplines

Psychology

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Joormann, J., McLean, S. A., Beaudoin, F. L., Huang, X., Stevens, J., Zeng, D., Neylan, T. C., Clifford, G. D., Linnstaedt, S. D., Germine, L. T., Rauch, S. L., Musey, P. I., Hendry, P. L., Sheikh, S., Jones, C. W., Punches, B. E., Fermann, G. J., Hudak, L. A., Mohiuddin, K., ... Kessler, R. C. (2020). Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study. Psychological Medicine. https://doi.org/10.1017/S0033291720003773

Joormann, J, McLean, SA, Beaudoin, FL, Huang, X, Stevens, J, Zeng, D, Neylan, TC, Clifford, GD, Linnstaedt, SD, Germine, LT, Rauch, SL, Musey, PI, Hendry, PL, Sheikh, S, Jones, CW, Punches, BE, Fermann, GJ, Hudak, LA, Mohiuddin, K, MURTY, TVISHNU, McGrath, ME, Haran, JP, Pascual, JL, Seamon, M, Peak, DA, Pearson, C, Domeier, RM, Sergot, P, Merchant, RC, Sanchez, LD, Rathlev, NK, Peacock, WF, Bruce, S, Barch, DM, Pizzagalli, DA, Luna, B, Harte, SE, Hwang, I, Lee, S, Sampson, NA, Koenen, KC, Ressler, KJ & Kessler, RC 2020, 'Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study', Psychological Medicine. https://doi.org/10.1017/S0033291720003773

@article{db0feed8895b468297e97bce2a8181dd,

title = "Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study",

abstract = " Background This is the first report on the association between trauma exposure and depression from the A dvancing U nderstanding of R ec O very afte R traum A (AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. Methods We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression. Results Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma. Conclusions These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure. ",

keywords = "Anxiety, PTSD, depression, trauma",

author = "Jutta Joormann and McLean, {Samuel A.} and Beaudoin, {Francesca L.} and Xinming Huang and Jennifer Stevens and Donglin Zeng and Neylan, {Thomas C} and Clifford, {Gari D} and Linnstaedt, {Sarah D.} and Germine, {Laura T.} and Rauch, {Scott L.} and Musey, {Paul I.} and Hendry, {Phyllis L.} and Sophia Sheikh and Jones, {Christopher W.} and Punches, {Brittany E.} and Fermann, {Gregory J.} and Hudak, {Lauren A.} and Kamran Mohiuddin and MURTY, {T. VISHNU} and McGrath, {Meghan E.} and Haran, {John P.} and Pascual, {Jose L} and Mark Seamon and Peak, {David A.} and Claire Pearson and Domeier, {Robert M.} and Paulina Sergot and Merchant, {Roland C.} and Sanchez, {Leon D.} and Rathlev, {Niels K.} and Peacock, {William F.} and Steven Bruce and Barch, {Deanna M} and Pizzagalli, {Diego A.} and Beatriz Luna and Harte, {Steven E.} and Irving Hwang and Sue Lee and Sampson, {Nancy A.} and Koenen, {Karestan C.} and Ressler, {Kerry J.} and Kessler, {Ronald C.}",

note = "Lobo, Jarred J. McLean, Samuel A. Tungate, Andrew S. Peak, David A. Swor, Robert A. Rathlev, Niels K. Hendry, Phyllis L. and Linnstaedt, Sarah D. 2021. Polygenic risk scoring to assess genetic overlap and protective factors influencing posttraumatic stress, depression, and chronic pain after motor vehicle collision trauma. Translational Psychiatry, Vol.",

year = "2020",

doi = "10.1017/S0033291720003773",

language = "American English",

journal = "Psychological Medicine",

}

TY - JOUR

T1 - Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study

AU - Joormann, Jutta

AU - McLean, Samuel A.

AU - Beaudoin, Francesca L.

AU - Huang, Xinming

AU - Stevens, Jennifer

AU - Zeng, Donglin

AU - Neylan, Thomas C

AU - Clifford, Gari D

AU - Linnstaedt, Sarah D.

AU - Germine, Laura T.

AU - Rauch, Scott L.

AU - Musey, Paul I.

AU - Hendry, Phyllis L.

AU - Sheikh, Sophia

AU - Jones, Christopher W.

AU - Punches, Brittany E.

AU - Fermann, Gregory J.

AU - Hudak, Lauren A.

AU - Mohiuddin, Kamran

AU - MURTY, T. VISHNU

AU - McGrath, Meghan E.

AU - Haran, John P.

AU - Pascual, Jose L

AU - Seamon, Mark

AU - Peak, David A.

AU - Pearson, Claire

AU - Domeier, Robert M.

AU - Sergot, Paulina

AU - Merchant, Roland C.

AU - Sanchez, Leon D.

AU - Rathlev, Niels K.

AU - Peacock, William F.

AU - Bruce, Steven

AU - Barch, Deanna M

AU - Pizzagalli, Diego A.

AU - Luna, Beatriz

AU - Harte, Steven E.

AU - Hwang, Irving

AU - Lee, Sue

AU - Sampson, Nancy A.

AU - Koenen, Karestan C.

AU - Ressler, Kerry J.

AU - Kessler, Ronald C.

N1 - Lobo, Jarred J. McLean, Samuel A. Tungate, Andrew S. Peak, David A. Swor, Robert A. Rathlev, Niels K. Hendry, Phyllis L. and Linnstaedt, Sarah D. 2021. Polygenic risk scoring to assess genetic overlap and protective factors influencing posttraumatic stress, depression, and chronic pain after motor vehicle collision trauma. Translational Psychiatry, Vol.

PY - 2020

Y1 - 2020

N2 - Background This is the first report on the association between trauma exposure and depression from the A dvancing U nderstanding of R ec O very afte R traum A (AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. Methods We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression. Results Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma. Conclusions These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.

AB - Background This is the first report on the association between trauma exposure and depression from the A dvancing U nderstanding of R ec O very afte R traum A (AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. Methods We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression. Results Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma. Conclusions These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.

KW - Anxiety

KW - PTSD

KW - depression

KW - trauma

UR - https://doi.org/10.1017/S0033291720003773

U2 - 10.1017/S0033291720003773

DO - 10.1017/S0033291720003773

M3 - Article

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study

Abstract

Keywords

Disciplines

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