Ruthenium complexes of the general formula [RuCl 2 (PHOX) 2 ] as precatalysts in propargylic substitution reactions

Negar Jourabchian; Kellsie Jurkowski; Eike B. Bauer

doi:10.1016/j.catcom.2017.12.014

Ruthenium complexes of the general formula [RuCl 2 (PHOX) 2 ] as precatalysts in propargylic substitution reactions

Negar Jourabchian, Kellsie Jurkowski, Eike B. Bauer

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

After activation by chloride abstraction utilizing NaBArF as an activator (BArF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), a complex of the general formula [RuCl2 (PHOX)2 ] was utilized as a catalyst in propargylic substitution reactions, where PHOX is a phosphinooxazoline ligand. Oxygen and nitrogen-centered nucleophiles could be employed in the substitution of a propargylic acetate to obtain the corresponding propargylic substitution products in 87% to 9% isolated yields (45 °C, 16 h reaction time, toluene solvent, 1-2 mol% catalyst loading, 1-2 mol% activator).

Original language	American English
Journal	Catalysis Communications
Volume	106
DOIs	https://doi.org/10.1016/j.catcom.2017.12.014
State	Published - Jan 3 2018

Disciplines

Inorganic Chemistry

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Cite this

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title = "Ruthenium complexes of the general formula [RuCl 2 (PHOX) 2 ] as precatalysts in propargylic substitution reactions",

abstract = " After activation by chloride abstraction utilizing NaBArF as an activator (BArF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), a complex of the general formula [RuCl2 (PHOX)2 ] was utilized as a catalyst in propargylic substitution reactions, where PHOX is a phosphinooxazoline ligand. Oxygen and nitrogen-centered nucleophiles could be employed in the substitution of a propargylic acetate to obtain the corresponding propargylic substitution products in 87% to 9% isolated yields (45 °C, 16 h reaction time, toluene solvent, 1-2 mol% catalyst loading, 1-2 mol% activator). ",

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language = "American English",

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AU - Jourabchian, Negar

AU - Jurkowski, Kellsie

AU - Bauer, Eike B.

PY - 2018/1/3

Y1 - 2018/1/3

N2 - After activation by chloride abstraction utilizing NaBArF as an activator (BArF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), a complex of the general formula [RuCl2 (PHOX)2 ] was utilized as a catalyst in propargylic substitution reactions, where PHOX is a phosphinooxazoline ligand. Oxygen and nitrogen-centered nucleophiles could be employed in the substitution of a propargylic acetate to obtain the corresponding propargylic substitution products in 87% to 9% isolated yields (45 °C, 16 h reaction time, toluene solvent, 1-2 mol% catalyst loading, 1-2 mol% activator).

AB - After activation by chloride abstraction utilizing NaBArF as an activator (BArF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), a complex of the general formula [RuCl2 (PHOX)2 ] was utilized as a catalyst in propargylic substitution reactions, where PHOX is a phosphinooxazoline ligand. Oxygen and nitrogen-centered nucleophiles could be employed in the substitution of a propargylic acetate to obtain the corresponding propargylic substitution products in 87% to 9% isolated yields (45 °C, 16 h reaction time, toluene solvent, 1-2 mol% catalyst loading, 1-2 mol% activator).

U2 - 10.1016/j.catcom.2017.12.014

DO - 10.1016/j.catcom.2017.12.014

M3 - Article

VL - 106

JO - Catalysis Communications

JF - Catalysis Communications

ER -