Replacing Proline at the Apex of Heptapeptide-Based Chloride Ion Transporters Alters Their Properties and Their Ionophoretic Efficacy

Paul H. Schlesinger; Riccardo Ferdani; Jolanta Pajewska; Robert Pajewski; George W. Gokel

doi:10.1039/B206570N

Replacing Proline at the Apex of Heptapeptide-Based Chloride Ion Transporters Alters Their Properties and Their Ionophoretic Efficacy

Paul H. Schlesinger, Riccardo Ferdani, Jolanta Pajewska, Robert Pajewski, George W. Gokel

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	New Journal of Chemistry
Volume	27
DOIs	https://doi.org/10.1039/B206570N
State	Published - Jan 8 2003
Externally published	Yes

Disciplines

Biochemistry
Organic Chemistry
Inorganic Chemistry

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@article{1036c4a8ad8648bba85f729ca0899de9,

title = "Replacing Proline at the Apex of Heptapeptide-Based Chloride Ion Transporters Alters Their Properties and Their Ionophoretic Efficacy",

author = "Schlesinger, {Paul H.} and Riccardo Ferdani and Jolanta Pajewska and Robert Pajewski and Gokel, {George W.}",

note = "A membrane anchored heptapeptide, (CH)NHCOCHOCHCO-NH-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OCHPh, has proved to be a selective chloride anion transporter that functions in phospholipid bilayer membranes. When Pro was replaced by the natural amino acid Leu, the activity decreased dramatically. In the present study, Pro is replaced by pipecolic acid ( homoproline, Pip); the resulting anchored heptapeptide is a membrane active, chloride selective transporter.",

year = "2003",

month = jan,

day = "8",

doi = "10.1039/B206570N",

language = "American English",

volume = "27",

journal = "New Journal of Chemistry",

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TY - JOUR

T1 - Replacing Proline at the Apex of Heptapeptide-Based Chloride Ion Transporters Alters Their Properties and Their Ionophoretic Efficacy

AU - Schlesinger, Paul H.

AU - Ferdani, Riccardo

AU - Pajewska, Jolanta

AU - Pajewski, Robert

AU - Gokel, George W.

N1 - A membrane anchored heptapeptide, (CH)NHCOCHOCHCO-NH-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OCHPh, has proved to be a selective chloride anion transporter that functions in phospholipid bilayer membranes. When Pro was replaced by the natural amino acid Leu, the activity decreased dramatically. In the present study, Pro is replaced by pipecolic acid ( homoproline, Pip); the resulting anchored heptapeptide is a membrane active, chloride selective transporter.

PY - 2003/1/8

Y1 - 2003/1/8

UR - http://pubs.rsc.org/en/content/articlelanding/2003/nj/b206570n#!

U2 - 10.1039/B206570N

DO - 10.1039/B206570N

M3 - Article

VL - 27

JO - New Journal of Chemistry

JF - New Journal of Chemistry

ER -

Replacing Proline at the Apex of Heptapeptide-Based Chloride Ion Transporters Alters Their Properties and Their Ionophoretic Efficacy

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