Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

Xuemin Wang

doi:10.1042/BJ20150089

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

Xuemin Wang

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

E ukaryotic elongation factor 2 kinase (eEF2K) is activated under diverse stress conditions, where it aids cell survival but also undergoes degradation. We show that degradation of eEF2K requires it to be in an active state but does not require its activity.

Original language	American English
Journal	Biochemical Journal
Volume	467
DOIs	https://doi.org/10.1042/BJ20150089
State	Published - 2015

Keywords

autophosphorylation
degradation
eukaryotic elongation factor 2 kinase (eEF2K)
phosphodegron
α-kinase

Disciplines

Chemistry

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10.1042/BJ20150089License: Unspecified

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@article{6184d2965a6d42069ea6661e85303bfb,

title = "Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity",

abstract = " E ukaryotic elongation factor 2 kinase (eEF2K) is activated under diverse stress conditions, where it aids cell survival but also undergoes degradation. We show that degradation of eEF2K requires it to be in an active state but does not require its activity. ",

keywords = "autophosphorylation, degradation, eukaryotic elongation factor 2 kinase (eEF2K), phosphodegron, α-kinase",

author = "Xuemin Wang",

note = "Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical protein kinase which negatively regulates protein synthesis, is activated under stress conditions and plays a role in cytoprotection, e.g. in cancer cells. It is regarded as a possible target for therapeutic intervention in solid tumours.",

year = "2015",

doi = "10.1042/BJ20150089",

language = "American English",

volume = "467",

journal = "Biochemical Journal",

}

TY - JOUR

T1 - Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

AU - Wang, Xuemin

N1 - Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical protein kinase which negatively regulates protein synthesis, is activated under stress conditions and plays a role in cytoprotection, e.g. in cancer cells. It is regarded as a possible target for therapeutic intervention in solid tumours.

PY - 2015

Y1 - 2015

N2 - E ukaryotic elongation factor 2 kinase (eEF2K) is activated under diverse stress conditions, where it aids cell survival but also undergoes degradation. We show that degradation of eEF2K requires it to be in an active state but does not require its activity.

AB - E ukaryotic elongation factor 2 kinase (eEF2K) is activated under diverse stress conditions, where it aids cell survival but also undergoes degradation. We show that degradation of eEF2K requires it to be in an active state but does not require its activity.

KW - autophosphorylation

KW - degradation

KW - eukaryotic elongation factor 2 kinase (eEF2K)

KW - phosphodegron

KW - α-kinase

UR - https://doi.org/10.1042/BJ20150089

U2 - 10.1042/BJ20150089

DO - 10.1042/BJ20150089

M3 - Article

VL - 467

JO - Biochemical Journal

JF - Biochemical Journal

ER -

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

Abstract

Keywords

Disciplines

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