Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.

James K. Bashkin; Karl Aston; Joseph P. Ramos; Kevin J. Koeller; Rupesh Nanjunda; Gaofei He; Cynthia M. Dupureur; W. David Wilson

doi:10.1016/j.biochi.2012.09.023

Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.

James K. Bashkin, Karl Aston, Joseph P. Ramos, Kevin J. Koeller, Rupesh Nanjunda, Gaofei He, Cynthia M. Dupureur, W. David Wilson

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biochimie
Volume	95
DOIs	https://doi.org/10.1016/j.biochi.2012.09.023
State	Published - Jan 2 2013

Disciplines

Biochemistry
Molecular Biology

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title = "Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.",

author = "Bashkin, \{James K.\} and Karl Aston and Ramos, \{Joseph P.\} and Koeller, \{Kevin J.\} and Rupesh Nanjunda and Gaofei He and Dupureur, \{Cynthia M.\} and Wilson, \{W. David\}",

note = "Biochimie. 2013 Feb;95(2):271-9. doi: 10.1016/j.biochi.2012.09.023. Epub 2012 Sep 27. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.",

year = "2013",

month = jan,

day = "2",

doi = "10.1016/j.biochi.2012.09.023",

language = "American English",

volume = "95",

journal = "Biochimie",

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TY - JOUR

T1 - Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.

AU - Bashkin, James K.

AU - Aston, Karl

AU - Ramos, Joseph P.

AU - Koeller, Kevin J.

AU - Nanjunda, Rupesh

AU - He, Gaofei

AU - Dupureur, Cynthia M.

AU - Wilson, W. David

N1 - Biochimie. 2013 Feb;95(2):271-9. doi: 10.1016/j.biochi.2012.09.023. Epub 2012 Sep 27. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

PY - 2013/1/2

Y1 - 2013/1/2

UR - https://www.ncbi.nlm.nih.gov/pubmed/23023196

U2 - 10.1016/j.biochi.2012.09.023

DO - 10.1016/j.biochi.2012.09.023

M3 - Article

VL - 95

JO - Biochimie

JF - Biochimie

ER -

Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.

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