Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study

Jutta Joormann; Hannah N. Ziobrowski; Andrew J. King; Sarah M. Gildea; Sue Lee; Nancy A. Sampson; Stacey L. House; Francesca L. Beaudoin; Xinming An; Jennifer Stevens; Donglin Zeng; Thomas C. Neylan; Gari D. Clifford; Sarah D. Linnstaedt; Laura T. Germine; Kenneth A. Bollen; Scott L. Rauch; John P. Haran; Alan B. Storrow; Paul I. Musey Jr.; Phyllis L. Hendry; Sophia Sheikh; Christopher W. Jones; Brittany E. Punches; Meghan E. McGrath; Lauren A. Hudak; Jose L. Pascual; Mark J. Seamon; Anna Marie Chang; Claire Pearson; David A. Peak; Robert M. Domeier; Niels K. Rathlev; Brian J. O'Neil; Leon D. Sanchez; Steven Bruce; Mark L. Miller; Robert H. Pietrzak; Deanna M. Barch; Diego A. Pizzagalli; Steven E. Harte; James M. Elliott; Karestan C. Koenen; Samuel A. McLean; Ronald C. Kessler

doi:10.1002/DA.23223

Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study

Jutta Joormann, Hannah N. Ziobrowski, Andrew J. King, Sarah M. Gildea, Sue Lee, Nancy A. Sampson, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Paul I. Musey Jr.Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Anna Marie Chang, Claire Pearson, David A. Peak, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven Bruce, Mark L. Miller, Robert H. Pietrzak, Deanna M. Barch, Diego A. Pizzagalli, Steven E. Harte, James M. Elliott, Karestan C. Koenen, Samuel A. McLean, Ronald C. Kessler

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

 Background
 A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions.
 Methods
 Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders.
 Results
 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6–7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders.
 Conclusions
 Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.

Original language	American English
Journal	Depression and Anxiety
Volume	39
DOIs	https://doi.org/10.1002/DA.23223
State	Published - Jan 2022

Disciplines

Psychiatry and Psychology

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Joormann, J., Ziobrowski, H. N., King, A. J., Gildea, S. M., Lee, S., Sampson, N. A., House, S. L., Beaudoin, F. L., An, X., Stevens, J., Zeng, D., Neylan, T. C., Clifford, G. D., Linnstaedt, S. D., Germine, L. T., Bollen, K. A., Rauch, S. L., Haran, J. P., Storrow, A. B., ... Kessler, R. C. (2022). Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study. Depression and Anxiety, 39. https://doi.org/10.1002/DA.23223

Joormann, J, Ziobrowski, HN, King, AJ, Gildea, SM, Lee, S, Sampson, NA, House, SL, Beaudoin, FL, An, X, Stevens, J, Zeng, D, Neylan, TC, Clifford, GD, Linnstaedt, SD, Germine, LT, Bollen, KA, Rauch, SL, Haran, JP, Storrow, AB, Musey Jr., PI, Hendry, PL, Sheikh, S, Jones, CW, Punches, BE, McGrath, ME, Hudak, LA, Pascual, JL, Seamon, MJ, Chang, AM, Pearson, C, Peak, DA, Domeier, RM, Rathlev, NK, O'Neil, BJ, Sanchez, LD, Bruce, S, Miller, ML, Pietrzak, RH, Barch, DM, Pizzagalli, DA, Harte, SE, Elliott, JM, Koenen, KC, McLean, SA & Kessler, RC 2022, 'Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study', Depression and Anxiety, vol. 39. https://doi.org/10.1002/DA.23223

@article{b5c41ac6a9be4843ab2806418fce0d51,

title = "Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study",

abstract = " Background A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions. Methods Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders. Results 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6–7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders. Conclusions Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.",

author = "Jutta Joormann and Ziobrowski, {Hannah N.} and King, {Andrew J.} and Gildea, {Sarah M.} and Sue Lee and Sampson, {Nancy A.} and House, {Stacey L.} and Beaudoin, {Francesca L.} and Xinming An and Jennifer Stevens and Donglin Zeng and Neylan, {Thomas C.} and Clifford, {Gari D.} and Linnstaedt, {Sarah D.} and Germine, {Laura T.} and Bollen, {Kenneth A.} and Rauch, {Scott L.} and Haran, {John P.} and Storrow, {Alan B.} and {Musey Jr.}, {Paul I.} and Hendry, {Phyllis L.} and Sophia Sheikh and Jones, {Christopher W.} and Punches, {Brittany E.} and McGrath, {Meghan E.} and Hudak, {Lauren A.} and Pascual, {Jose L.} and Seamon, {Mark J.} and Chang, {Anna Marie} and Claire Pearson and Peak, {David A.} and Domeier, {Robert M.} and Rathlev, {Niels K.} and O'Neil, {Brian J.} and Sanchez, {Leon D.} and Steven Bruce and Miller, {Mark L.} and Pietrzak, {Robert H.} and Barch, {Deanna M.} and Pizzagalli, {Diego A.} and Harte, {Steven E.} and Elliott, {James M.} and Koenen, {Karestan C.} and McLean, {Samuel A.} and Kessler, {Ronald C.}",

year = "2022",

month = jan,

doi = "10.1002/DA.23223",

language = "American English",

volume = "39",

journal = "Depression and Anxiety",

}

TY - JOUR

T1 - Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study

AU - Joormann, Jutta

AU - Ziobrowski, Hannah N.

AU - King, Andrew J.

AU - Gildea, Sarah M.

AU - Lee, Sue

AU - Sampson, Nancy A.

AU - House, Stacey L.

AU - Beaudoin, Francesca L.

AU - An, Xinming

AU - Stevens, Jennifer

AU - Zeng, Donglin

AU - Neylan, Thomas C.

AU - Clifford, Gari D.

AU - Linnstaedt, Sarah D.

AU - Germine, Laura T.

AU - Bollen, Kenneth A.

AU - Rauch, Scott L.

AU - Haran, John P.

AU - Storrow, Alan B.

AU - Musey Jr., Paul I.

AU - Hendry, Phyllis L.

AU - Sheikh, Sophia

AU - Jones, Christopher W.

AU - Punches, Brittany E.

AU - McGrath, Meghan E.

AU - Hudak, Lauren A.

AU - Pascual, Jose L.

AU - Seamon, Mark J.

AU - Chang, Anna Marie

AU - Pearson, Claire

AU - Peak, David A.

AU - Domeier, Robert M.

AU - Rathlev, Niels K.

AU - O'Neil, Brian J.

AU - Sanchez, Leon D.

AU - Bruce, Steven

AU - Miller, Mark L.

AU - Pietrzak, Robert H.

AU - Barch, Deanna M.

AU - Pizzagalli, Diego A.

AU - Harte, Steven E.

AU - Elliott, James M.

AU - Koenen, Karestan C.

AU - McLean, Samuel A.

AU - Kessler, Ronald C.

PY - 2022/1

Y1 - 2022/1

N2 - Background A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions. Methods Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders. Results 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6–7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders. Conclusions Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.

AB - Background A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions. Methods Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders. Results 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6–7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders. Conclusions Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.

UR - https://doi.org/10.1002/DA.23223

U2 - 10.1002/DA.23223

DO - 10.1002/DA.23223

M3 - Article

VL - 39

JO - Depression and Anxiety

JF - Depression and Anxiety

ER -

Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study

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