Population structure of avian malaria parasites

Meghann B. Humphries; Matthew T. Stacy; Robert E. Ricklefs

doi:10.1002/ece3.5356

Population structure of avian malaria parasites

Meghann B. Humphries, Matthew T. Stacy, Robert E. Ricklefs

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

<div class="line" id="line-11"> The geographic distribution of genetic diversity in malaria parasite populations (Apicomplexa: Haemosporida) presumably influences local patterns of virulence and the evolution of host&hyphen;resistance, but little is known about population genetic structure in these parasites. We assess the distribution of genetic diversity in the partial Domain I of apical membrane antigen 1  (AMA 1)  in three mtDNA &hyphen;defined lineages of avian  Plasmodium  to determine spatial population structure and host–parasite genetic relationships. We find that one parasite lineage is genetically differentiated in association with a single host genus and among some locations, but not with respect to other hosts. Two other parasite lineages are undifferentiated with respect to host species but exhibit geographic differentiation that is inconsistent with shared geographic barriers or with isolation&hyphen;by&hyphen;distance. Additional differentiation within two other lineages is unassociated with host species or location; in one case, we tentatively interpret this differentiation as the result of mitochondrial introgression from one of the lineages into a second lineage. More sampling of nuclear genetic diversity within populations of avian  Plasmodium  is needed to rule out coinfection as a possible confounding factor. If coinfections are not responsible for these findings, further assessment is needed to determine the frequency of mitonuclear discordance and its implications for defining parasite lineages based on mitochondrial genetic variation. </div>

Original language	American English
Journal	Ecology and Evolution
Volume	9
DOIs	https://doi.org/10.1002/ece3.5356
State	Published - Jul 1 2019

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Zoology
Biology

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@article{cae5be8bdb084f86b92017d1563481d4,

title = "Population structure of avian malaria parasites",

abstract = " The geographic distribution of genetic diversity in malaria parasite populations (Apicomplexa: Haemosporida) presumably influences local patterns of virulence and the evolution of host&hyphen;resistance, but little is known about population genetic structure in these parasites. We assess the distribution of genetic diversity in the partial Domain I of apical membrane antigen 1  (AMA 1)  in three mtDNA &hyphen;defined lineages of avian  Plasmodium  to determine spatial population structure and host–parasite genetic relationships. We find that one parasite lineage is genetically differentiated in association with a single host genus and among some locations, but not with respect to other hosts. Two other parasite lineages are undifferentiated with respect to host species but exhibit geographic differentiation that is inconsistent with shared geographic barriers or with isolation&hyphen;by&hyphen;distance. Additional differentiation within two other lineages is unassociated with host species or location; in one case, we tentatively interpret this differentiation as the result of mitochondrial introgression from one of the lineages into a second lineage. More sampling of nuclear genetic diversity within populations of avian  Plasmodium  is needed to rule out coinfection as a possible confounding factor. If coinfections are not responsible for these findings, further assessment is needed to determine the frequency of mitonuclear discordance and its implications for defining parasite lineages based on mitochondrial genetic variation. ",

author = "Humphries, {Meghann B.} and Stacy, {Matthew T.} and Ricklefs, {Robert E.}",

note = "The geographic distribution of genetic diversity in malaria parasite populations (Apicomplexa: Haemosporida) presumably influences local patterns of virulence and the evolution of host‐resistance, but little is known about population genetic structure in these parasites.",

year = "2019",

month = jul,

day = "1",

doi = "10.1002/ece3.5356",

language = "American English",

volume = "9",

journal = "Ecology and Evolution",

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AU - Humphries, Meghann B.

AU - Stacy, Matthew T.

AU - Ricklefs, Robert E.

N1 - The geographic distribution of genetic diversity in malaria parasite populations (Apicomplexa: Haemosporida) presumably influences local patterns of virulence and the evolution of host‐resistance, but little is known about population genetic structure in these parasites.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The geographic distribution of genetic diversity in malaria parasite populations (Apicomplexa: Haemosporida) presumably influences local patterns of virulence and the evolution of host&hyphen;resistance, but little is known about population genetic structure in these parasites. We assess the distribution of genetic diversity in the partial Domain I of apical membrane antigen 1  (AMA 1)  in three mtDNA &hyphen;defined lineages of avian  Plasmodium  to determine spatial population structure and host–parasite genetic relationships. We find that one parasite lineage is genetically differentiated in association with a single host genus and among some locations, but not with respect to other hosts. Two other parasite lineages are undifferentiated with respect to host species but exhibit geographic differentiation that is inconsistent with shared geographic barriers or with isolation&hyphen;by&hyphen;distance. Additional differentiation within two other lineages is unassociated with host species or location; in one case, we tentatively interpret this differentiation as the result of mitochondrial introgression from one of the lineages into a second lineage. More sampling of nuclear genetic diversity within populations of avian  Plasmodium  is needed to rule out coinfection as a possible confounding factor. If coinfections are not responsible for these findings, further assessment is needed to determine the frequency of mitonuclear discordance and its implications for defining parasite lineages based on mitochondrial genetic variation.

AB - The geographic distribution of genetic diversity in malaria parasite populations (Apicomplexa: Haemosporida) presumably influences local patterns of virulence and the evolution of host&hyphen;resistance, but little is known about population genetic structure in these parasites. We assess the distribution of genetic diversity in the partial Domain I of apical membrane antigen 1  (AMA 1)  in three mtDNA &hyphen;defined lineages of avian  Plasmodium  to determine spatial population structure and host–parasite genetic relationships. We find that one parasite lineage is genetically differentiated in association with a single host genus and among some locations, but not with respect to other hosts. Two other parasite lineages are undifferentiated with respect to host species but exhibit geographic differentiation that is inconsistent with shared geographic barriers or with isolation&hyphen;by&hyphen;distance. Additional differentiation within two other lineages is unassociated with host species or location; in one case, we tentatively interpret this differentiation as the result of mitochondrial introgression from one of the lineages into a second lineage. More sampling of nuclear genetic diversity within populations of avian  Plasmodium  is needed to rule out coinfection as a possible confounding factor. If coinfections are not responsible for these findings, further assessment is needed to determine the frequency of mitonuclear discordance and its implications for defining parasite lineages based on mitochondrial genetic variation.

UR - https://onlinelibrary.wiley.com/doi/full/10.1002/ece3.5356

U2 - 10.1002/ece3.5356

DO - 10.1002/ece3.5356

M3 - Article

VL - 9

JO - Ecology and Evolution

JF - Ecology and Evolution

ER -

Population structure of avian malaria parasites

Abstract

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