Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries

Philip Moons; Koen Luyckx; Corina Thomet; Werner Budts; Junko Enomoto; Maayke A. Sluman; Chun-Wei Lu; Jamie L. Jackson; Paul Khairy; Stephen. C. Cook; Shanthi Chidambarathanu; Luis Alday; Katrine Eriksen; Mikael Dellborg; Malin Berghammer; Bengt Johansson; Andrew S. Mackie; Samuel A. Menahem; Maryanne Caruana; Gruschen Veldtman; Alexandra Soufi; Susan M. Fernandes; Kamila S. White; Edward Callus; Shelby Kutty; Fouke Ombelet; Silke Apers; Adrienne H. Kovacs

doi:10.1016/j.cjca.2020.03.044

Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries

Philip Moons, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke A. Sluman, Chun-Wei Lu, Jamie L. Jackson, Paul Khairy, Stephen. C. Cook, Shanthi Chidambarathanu, Luis Alday, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Andrew S. Mackie, Samuel A. Menahem, Maryanne Caruana, Gruschen VeldtmanAlexandra Soufi, Susan M. Fernandes, Kamila S. White, Edward Callus, Shelby Kutty, Fouke Ombelet, Silke Apers, Adrienne H. Kovacs

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

 Background
 We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of       congenital heart disease     (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects.
 Methods
 In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey,       Hospital Anxiety and Depression Scale     (HADS), linear analog scale (LAS) and       Satisfaction with Life Scale    , respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect.
 Results
 Patients with       coarctation of the aorta     and those with isolated       aortic valve disease     reported the best physical functioning, mental health, and QoL. Patients with       cyanotic heart disease     or       Eisenmenger syndrome     had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%).
 Conclusions
 Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

Original language	American English
Journal	Canadian Journal of Cardiology
Volume	37
DOIs	https://doi.org/10.1016/j.cjca.2020.03.044
State	Published - Feb 2021

Disciplines

Psychology

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Moons, P., Luyckx, K., Thomet, C., Budts, W., Enomoto, J., Sluman, M. A., Lu, C.-W., Jackson, J. L., Khairy, P., Cook, S. C., Chidambarathanu, S., Alday, L., Eriksen, K., Dellborg, M., Berghammer, M., Johansson, B., Mackie, A. S., Menahem, S. A., Caruana, M., ... Kovacs, A. H. (2021). Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries. Canadian Journal of Cardiology, 37. https://doi.org/10.1016/j.cjca.2020.03.044

Moons, P, Luyckx, K, Thomet, C, Budts, W, Enomoto, J, Sluman, MA, Lu, C-W, Jackson, JL, Khairy, P, Cook, SC, Chidambarathanu, S, Alday, L, Eriksen, K, Dellborg, M, Berghammer, M, Johansson, B, Mackie, AS, Menahem, SA, Caruana, M, Veldtman, G, Soufi, A, Fernandes, SM, White, KS, Callus, E, Kutty, S, Ombelet, F, Apers, S & Kovacs, AH 2021, 'Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries', Canadian Journal of Cardiology, vol. 37. https://doi.org/10.1016/j.cjca.2020.03.044

@article{7e5b5f5b143143ebb1a69a685f9a5049,

title = "Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries",

abstract = " Background We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale , respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.",

author = "Philip Moons and Koen Luyckx and Corina Thomet and Werner Budts and Junko Enomoto and Sluman, {Maayke A.} and Chun-Wei Lu and Jackson, {Jamie L.} and Paul Khairy and Cook, {Stephen. C.} and Shanthi Chidambarathanu and Luis Alday and Katrine Eriksen and Mikael Dellborg and Malin Berghammer and Bengt Johansson and Mackie, {Andrew S.} and Menahem, {Samuel A.} and Maryanne Caruana and Gruschen Veldtman and Alexandra Soufi and Fernandes, {Susan M.} and White, {Kamila S.} and Edward Callus and Shelby Kutty and Fouke Ombelet and Silke Apers and Kovacs, {Adrienne H.}",

year = "2021",

month = feb,

doi = "10.1016/j.cjca.2020.03.044",

language = "American English",

volume = "37",

journal = "Canadian Journal of Cardiology",

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TY - JOUR

T1 - Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries

AU - Moons, Philip

AU - Luyckx, Koen

AU - Thomet, Corina

AU - Budts, Werner

AU - Enomoto, Junko

AU - Sluman, Maayke A.

AU - Lu, Chun-Wei

AU - Jackson, Jamie L.

AU - Khairy, Paul

AU - Cook, Stephen. C.

AU - Chidambarathanu, Shanthi

AU - Alday, Luis

AU - Eriksen, Katrine

AU - Dellborg, Mikael

AU - Berghammer, Malin

AU - Johansson, Bengt

AU - Mackie, Andrew S.

AU - Menahem, Samuel A.

AU - Caruana, Maryanne

AU - Veldtman, Gruschen

AU - Soufi, Alexandra

AU - Fernandes, Susan M.

AU - White, Kamila S.

AU - Callus, Edward

AU - Kutty, Shelby

AU - Ombelet, Fouke

AU - Apers, Silke

AU - Kovacs, Adrienne H.

PY - 2021/2

Y1 - 2021/2

N2 - Background We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale , respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

AB - Background We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale , respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

U2 - 10.1016/j.cjca.2020.03.044

DO - 10.1016/j.cjca.2020.03.044

M3 - Article

VL - 37

JO - Canadian Journal of Cardiology

JF - Canadian Journal of Cardiology

ER -