Pain in adults with congenital heart disease - An international perspective

Allison Leibold; Erin Eichler; Sukyung Chung; Philip Moons; Adrienne H. Kovacs; Koen Luyckx; Silke Apers; Corina Thomet; Werner Budts; Junko Enomoto; Maayke A. Sluman; Jou-Kou Wang; Jamie L. Jackson; Paul Khairy; Stephen C. Cook; Shanthi Chidambarathanu; Luis Alday; Erwin Oechslin; Katrine Eriksen; Mikael Dellborg; Malin Berghammer; Bengt Erik Johansson; Andrew S. Mackie; Samuel Menahem; Maryanne Caruana; Gruschen Veldtman; Alexandra Soufi; Kamila S. White; Edward Callus; Shelby Kutty; Susan M. Fernandes

doi:10.1016/j.ijcchd.2021.100200

Pain in adults with congenital heart disease - An international perspective

Allison Leibold, Erin Eichler, Sukyung Chung, Philip Moons, Adrienne H. Kovacs, Koen Luyckx, Silke Apers, Corina Thomet, Werner Budts, Junko Enomoto, Maayke A. Sluman, Jou-Kou Wang, Jamie L. Jackson, Paul Khairy, Stephen C. Cook, Shanthi Chidambarathanu, Luis Alday, Erwin Oechslin, Katrine Eriksen, Mikael DellborgMalin Berghammer, Bengt Erik Johansson, Andrew S. Mackie, Samuel Menahem, Maryanne Caruana, Gruschen Veldtman, Alexandra Soufi, Kamila S. White, Edward Callus, Shelby Kutty, Susan M. Fernandes

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

<div class="line" id="line-19"> Background</div><div class="line" id="line-45"> Patients with  <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/adult-congenital-heart-disease"> <span style="color: rgb(46, 46, 46);"> adult congenital heart disease </span> </a>  (ACHD) have many risk factors for chronic pain such as prior cardiac interventions and adult comorbidities. However, the prevalence of chronic pain has not been well described in this population. We sought to determine the prevalence of pain in a large international cohort of patients with ACHD.</div><div class="line" id="line-52"> Methods</div><div class="line" id="line-54"> Data from the APPROACH-IS dataset was utilized for this study which includes 4028 patients with ACHD from 15 different countries. The prevalence of pain was assessed under the health status patient reported outcome domain utilizing the EuroQol-5D 3 level version tool. Multivariable  <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/logistic-regression-analysis"> <span style="color: rgb(46, 46, 46);"> logistic regression </span> </a>  was used to assess differences across countries in pain, taking into account country-level random effects for clustering across observations within each country.</div><div class="line" id="line-61"> Results</div><div class="line" id="line-63"> A total of 3832 patients with ACHD met the study criteria, median age 32 years [IQR 25, 42], 52.6% females. The prevalence of at least moderate pain was reported by 28.9% (95% CO 27.5 &ZeroWidthSpace;= &ZeroWidthSpace;30.3%) of participants. Pain was associated with country of origin, age, gender, background, education and marital status as well as several clinical variables including disease complexity, cardiac device presence, history of heart failure, psychiatric conditions and presence of other medical conditions. Those with pain had lower levels of perceived health and a lower quality of life score.</div><div class="line" id="line-65"> Conclusion</div><div class="line" id="line-67"> Pain in patients with ACHD is common, impacting nearly one-third of patients. Given the far reaching implications of pain in patients with ACHD, further study of pain characteristics and treatment management appear warranted.</div><div class="line" id="line-71"> <br/></div><div class="line" id="line-69"> <br/></div>

Original language	American English
Journal	International Journal of Cardiology Congenital Heart Disease
Volume	5
DOIs	https://doi.org/10.1016/j.ijcchd.2021.100200
State	Published - Oct 2021

Keywords

Adult congenital heart disease
Chronic pain
Congenital heart disease
Patient reported outcomes

Disciplines

Psychology

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Leibold, A., Eichler, E., Chung, S., Moons, P., Kovacs, A. H., Luyckx, K., Apers, S., Thomet, C., Budts, W., Enomoto, J., Sluman, M. A., Wang, J.-K., Jackson, J. L., Khairy, P., Cook, S. C., Chidambarathanu, S., Alday, L., Oechslin, E., Eriksen, K., ... Fernandes, S. M. (2021). Pain in adults with congenital heart disease - An international perspective. International Journal of Cardiology Congenital Heart Disease, 5. https://doi.org/10.1016/j.ijcchd.2021.100200

Leibold, A, Eichler, E, Chung, S, Moons, P, Kovacs, AH, Luyckx, K, Apers, S, Thomet, C, Budts, W, Enomoto, J, Sluman, MA, Wang, J-K, Jackson, JL, Khairy, P, Cook, SC, Chidambarathanu, S, Alday, L, Oechslin, E, Eriksen, K, Dellborg, M, Berghammer, M, Johansson, BE, Mackie, AS, Menahem, S, Caruana, M, Veldtman, G, Soufi, A, White, KS, Callus, E, Kutty, S & Fernandes, SM 2021, 'Pain in adults with congenital heart disease - An international perspective', International Journal of Cardiology Congenital Heart Disease, vol. 5. https://doi.org/10.1016/j.ijcchd.2021.100200

@article{2d7dca2a412b4cab8b5bc0ff47107503,

title = "Pain in adults with congenital heart disease - An international perspective",

abstract = " Background Patients with  adult congenital heart disease  (ACHD) have many risk factors for chronic pain such as prior cardiac interventions and adult comorbidities. However, the prevalence of chronic pain has not been well described in this population. We sought to determine the prevalence of pain in a large international cohort of patients with ACHD. Methods Data from the APPROACH-IS dataset was utilized for this study which includes 4028 patients with ACHD from 15 different countries. The prevalence of pain was assessed under the health status patient reported outcome domain utilizing the EuroQol-5D 3 level version tool. Multivariable  logistic regression  was used to assess differences across countries in pain, taking into account country-level random effects for clustering across observations within each country. Results A total of 3832 patients with ACHD met the study criteria, median age 32 years [IQR 25, 42], 52.6% females. The prevalence of at least moderate pain was reported by 28.9% (95% CO 27.5 &ZeroWidthSpace;= &ZeroWidthSpace;30.3%) of participants. Pain was associated with country of origin, age, gender, background, education and marital status as well as several clinical variables including disease complexity, cardiac device presence, history of heart failure, psychiatric conditions and presence of other medical conditions. Those with pain had lower levels of perceived health and a lower quality of life score. Conclusion Pain in patients with ACHD is common, impacting nearly one-third of patients. Given the far reaching implications of pain in patients with ACHD, further study of pain characteristics and treatment management appear warranted. ",

keywords = "Adult congenital heart disease, Chronic pain, Congenital heart disease, Patient reported outcomes",

author = "Allison Leibold and Erin Eichler and Sukyung Chung and Philip Moons and Kovacs, {Adrienne H.} and Koen Luyckx and Silke Apers and Corina Thomet and Werner Budts and Junko Enomoto and Sluman, {Maayke A.} and Jou-Kou Wang and Jackson, {Jamie L.} and Paul Khairy and Cook, {Stephen C.} and Shanthi Chidambarathanu and Luis Alday and Erwin Oechslin and Katrine Eriksen and Mikael Dellborg and Malin Berghammer and Johansson, {Bengt Erik} and Mackie, {Andrew S.} and Samuel Menahem and Maryanne Caruana and Gruschen Veldtman and Alexandra Soufi and White, {Kamila S.} and Edward Callus and Shelby Kutty and Fernandes, {Susan M.}",

year = "2021",

month = oct,

doi = "10.1016/j.ijcchd.2021.100200",

language = "American English",

volume = "5",

journal = "International Journal of Cardiology Congenital Heart Disease",

}

TY - JOUR

T1 - Pain in adults with congenital heart disease - An international perspective

AU - Leibold, Allison

AU - Eichler, Erin

AU - Chung, Sukyung

AU - Moons, Philip

AU - Kovacs, Adrienne H.

AU - Luyckx, Koen

AU - Apers, Silke

AU - Thomet, Corina

AU - Budts, Werner

AU - Enomoto, Junko

AU - Sluman, Maayke A.

AU - Wang, Jou-Kou

AU - Jackson, Jamie L.

AU - Khairy, Paul

AU - Cook, Stephen C.

AU - Chidambarathanu, Shanthi

AU - Alday, Luis

AU - Oechslin, Erwin

AU - Eriksen, Katrine

AU - Dellborg, Mikael

AU - Berghammer, Malin

AU - Johansson, Bengt Erik

AU - Mackie, Andrew S.

AU - Menahem, Samuel

AU - Caruana, Maryanne

AU - Veldtman, Gruschen

AU - Soufi, Alexandra

AU - White, Kamila S.

AU - Callus, Edward

AU - Kutty, Shelby

AU - Fernandes, Susan M.

PY - 2021/10

Y1 - 2021/10

N2 - Background Patients with  adult congenital heart disease  (ACHD) have many risk factors for chronic pain such as prior cardiac interventions and adult comorbidities. However, the prevalence of chronic pain has not been well described in this population. We sought to determine the prevalence of pain in a large international cohort of patients with ACHD. Methods Data from the APPROACH-IS dataset was utilized for this study which includes 4028 patients with ACHD from 15 different countries. The prevalence of pain was assessed under the health status patient reported outcome domain utilizing the EuroQol-5D 3 level version tool. Multivariable  logistic regression  was used to assess differences across countries in pain, taking into account country-level random effects for clustering across observations within each country. Results A total of 3832 patients with ACHD met the study criteria, median age 32 years [IQR 25, 42], 52.6% females. The prevalence of at least moderate pain was reported by 28.9% (95% CO 27.5 &ZeroWidthSpace;= &ZeroWidthSpace;30.3%) of participants. Pain was associated with country of origin, age, gender, background, education and marital status as well as several clinical variables including disease complexity, cardiac device presence, history of heart failure, psychiatric conditions and presence of other medical conditions. Those with pain had lower levels of perceived health and a lower quality of life score. Conclusion Pain in patients with ACHD is common, impacting nearly one-third of patients. Given the far reaching implications of pain in patients with ACHD, further study of pain characteristics and treatment management appear warranted.

AB - Background Patients with  adult congenital heart disease  (ACHD) have many risk factors for chronic pain such as prior cardiac interventions and adult comorbidities. However, the prevalence of chronic pain has not been well described in this population. We sought to determine the prevalence of pain in a large international cohort of patients with ACHD. Methods Data from the APPROACH-IS dataset was utilized for this study which includes 4028 patients with ACHD from 15 different countries. The prevalence of pain was assessed under the health status patient reported outcome domain utilizing the EuroQol-5D 3 level version tool. Multivariable  logistic regression  was used to assess differences across countries in pain, taking into account country-level random effects for clustering across observations within each country. Results A total of 3832 patients with ACHD met the study criteria, median age 32 years [IQR 25, 42], 52.6% females. The prevalence of at least moderate pain was reported by 28.9% (95% CO 27.5 &ZeroWidthSpace;= &ZeroWidthSpace;30.3%) of participants. Pain was associated with country of origin, age, gender, background, education and marital status as well as several clinical variables including disease complexity, cardiac device presence, history of heart failure, psychiatric conditions and presence of other medical conditions. Those with pain had lower levels of perceived health and a lower quality of life score. Conclusion Pain in patients with ACHD is common, impacting nearly one-third of patients. Given the far reaching implications of pain in patients with ACHD, further study of pain characteristics and treatment management appear warranted.

KW - Adult congenital heart disease

KW - Chronic pain

KW - Congenital heart disease

KW - Patient reported outcomes

UR - https://doi.org/10.1016/j.ijcchd.2021.100200

U2 - 10.1016/j.ijcchd.2021.100200

DO - 10.1016/j.ijcchd.2021.100200

M3 - Article

VL - 5

JO - International Journal of Cardiology Congenital Heart Disease

JF - International Journal of Cardiology Congenital Heart Disease

ER -

Pain in adults with congenital heart disease - An international perspective

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