TY - JOUR
T1 - OFox Imidates as Versatile Glycosyl Donors for Chemical Glycosylation
AU - Nigudkar, Swati S.
AU - Wang, Tinghua
AU - Pistorio, Salvatore G.
AU - Yasomanee, Jagodige P.
AU - Stine, Keith J.
AU - Demchenko, Alexei V.
N1 - Previously we communicated 3,3-difluoroxindole (HOFox) - mediated glycosylations wherein 3,3-difluoro-3H-indol-2-yl (OFox) imidates were found to be key intermediates. Both the in situ synthesis from the corresponding glycosyl bromides and activation of the OFox imidates could be conducted in a regenerative 2017 Hot Articles in Organic and Biomolecular Chemistry
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Previously we communicated 3,3-difluoroxindole (HOFox) – mediated glycosylations wherein 3,3-difluoro-3 H -indol-2-yl (OFox) imidates were found to be key intermediates. Both the in situ synthesis from the corresponding glycosyl bromides and activation of the OFox imidates could be conducted in a regenerative fashion. Herein, we extend this study with the main focus on the synthesis of various OFox imidates and their investigation as glycosyl donors for chemical 1,2- cis and 1,2- trans glycosylation.
AB - Previously we communicated 3,3-difluoroxindole (HOFox) – mediated glycosylations wherein 3,3-difluoro-3 H -indol-2-yl (OFox) imidates were found to be key intermediates. Both the in situ synthesis from the corresponding glycosyl bromides and activation of the OFox imidates could be conducted in a regenerative fashion. Herein, we extend this study with the main focus on the synthesis of various OFox imidates and their investigation as glycosyl donors for chemical 1,2- cis and 1,2- trans glycosylation.
UR - https://pubs.rsc.org/en/content/articlelanding/2017/ob/c6ob02230h
UR - http://pubs.rsc.org/en/content/articlelanding/2017/ob/c6ob02230h
U2 - 10.1039/C6OB02230H
DO - 10.1039/C6OB02230H
M3 - Article
VL - 15
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
ER -