Nuclear translocation of proteins and the effect of phosphatidic acid

Hongyan Yao; Geliang Wang; Xuemin Wang

doi:10.4161/15592324.2014.977711

Nuclear translocation of proteins and the effect of phosphatidic acid

Hongyan Yao
, Geliang Wang
, Xuemin Wang

Research output: Contribution to journal › Article › peer-review

Abstract

Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the nucleus is not well understood. Recent results indicate that phospholipids, such as phosphatidic acid, play important roles in the intracellular translocation of proteins between the nucleus and cytoplasm.

Original language	American English
Journal	Plant Signaling & Behavior
Volume	9
DOIs	https://doi.org/10.4161/15592324.2014.977711
State	Published - Nov 3 2014
Externally published	Yes

Keywords

Arabidopsis
NLS
NPCs
PA
PLD
Phosphatidylinositol-5-bisphosphate
PtdIns(5)P
nuclear localization signal
nuclear pore complexes
phosphatidic acid
phospholipase D.
phospholipid
protein nuclear import

Disciplines

Biology
Biochemistry
Botany
Cell Biology

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10.4161/15592324.2014.977711License: Unspecified

Cite this

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title = "Nuclear translocation of proteins and the effect of phosphatidic acid",

abstract = " Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the nucleus is not well understood. Recent results indicate that phospholipids, such as phosphatidic acid, play important roles in the intracellular translocation of proteins between the nucleus and cytoplasm. ",

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author = "Hongyan Yao and Geliang Wang and Xuemin Wang",

note = "Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how protei ...",

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doi = "10.4161/15592324.2014.977711",

language = "American English",

volume = "9",

journal = "Plant Signaling \& Behavior",

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TY - JOUR

T1 - Nuclear translocation of proteins and the effect of phosphatidic acid

AU - Yao, Hongyan

AU - Wang, Geliang

AU - Wang, Xuemin

N1 - Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how protei ...

PY - 2014/11/3

Y1 - 2014/11/3

N2 - Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the nucleus is not well understood. Recent results indicate that phospholipids, such as phosphatidic acid, play important roles in the intracellular translocation of proteins between the nucleus and cytoplasm.

AB - Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the nucleus is not well understood. Recent results indicate that phospholipids, such as phosphatidic acid, play important roles in the intracellular translocation of proteins between the nucleus and cytoplasm.

KW - Arabidopsis

KW - NLS

KW - NPCs

KW - PA

KW - PLD

KW - Phosphatidylinositol-5-bisphosphate

KW - PtdIns(5)P

KW - nuclear localization signal

KW - nuclear pore complexes

KW - phosphatidic acid

KW - phospholipase D.

KW - phospholipid

KW - protein nuclear import

UR - https://www.ncbi.nlm.nih.gov/pubmed/25482760

U2 - 10.4161/15592324.2014.977711

DO - 10.4161/15592324.2014.977711

M3 - Article

VL - 9

JO - Plant Signaling & Behavior

JF - Plant Signaling & Behavior

ER -

Nuclear translocation of proteins and the effect of phosphatidic acid

Abstract

Keywords

Disciplines

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