Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one

Xin Jiang; Brad D. Manion; Ann Benz; Nigam P. Rath; Alex S. Evers; Charles F. Zorumski; Steven Mennerick; Douglas F. Covey

doi:10.1021/jm030302m

Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one

Xin Jiang, Brad D. Manion, Ann Benz, Nigam P. Rath, Alex S. Evers, Charles F. Zorumski, Steven Mennerick, Douglas F. Covey

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Medicinal Chemistry
Volume	46
DOIs	https://doi.org/10.1021/jm030302m
State	Published - Dec 1 2003

Disciplines

Biochemistry
Chemistry
Organic Chemistry

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Jiang, X., Manion, B. D., Benz, A., Rath, N. P., Evers, A. S., Zorumski, C. F., Mennerick, S., & Covey, D. F. (2003). Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry, 46. https://doi.org/10.1021/jm030302m

Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one. / Jiang, Xin; Manion, Brad D.; Benz, Ann et al.
In: Journal of Medicinal Chemistry, Vol. 46, 01.12.2003.

Research output: Contribution to journal › Article › peer-review

Jiang, X, Manion, BD, Benz, A, Rath, NP, Evers, AS, Zorumski, CF, Mennerick, S & Covey, DF 2003, 'Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one', Journal of Medicinal Chemistry, vol. 46. https://doi.org/10.1021/jm030302m

Jiang X, Manion BD, Benz A, Rath NP, Evers AS, Zorumski CF et al. Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 2003 Dec 1;46. doi: 10.1021/jm030302m

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title = "Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one",

author = "Xin Jiang and Manion, {Brad D.} and Ann Benz and Rath, {Nigam P.} and Evers, {Alex S.} and Zorumski, {Charles F.} and Steven Mennerick and Covey, {Douglas F.}",

note = "J Med Chem. 2003 Dec 4;46(25):5334-48. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.",

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AU - Jiang, Xin

AU - Manion, Brad D.

AU - Benz, Ann

AU - Rath, Nigam P.

AU - Evers, Alex S.

AU - Zorumski, Charles F.

AU - Mennerick, Steven

AU - Covey, Douglas F.

N1 - J Med Chem. 2003 Dec 4;46(25):5334-48. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

PY - 2003/12/1

Y1 - 2003/12/1

UR - https://www.ncbi.nlm.nih.gov/pubmed/14640542

U2 - 10.1021/jm030302m

DO - 10.1021/jm030302m

M3 - Article

VL - 46

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

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Neurosteroid analogues. 9. Conformationally constrained pregnanes: Structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one

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