Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study

Laura T. Germine; Jutta Joormann; Eliza Passell; Lauren A. Rutter; Luke M Scheuer; Paolo Martini; Irving Hwang; Sue Lee; Nancy A. Sampson; Deanna M. Barch; Stacey L. House; Francesca L. Beaudoin; Xinming An; Jennifer S. Stevens; Donglin Zeng; Sarah D. Linnstaedt; Tanja Jovanovic; Gari D. Clifford; Thomas C. Neylan; Scott L. Rauch; Christopher Lewandowski; Phyllis L. Hendry; Sophia Sheikh; Alan B. Storrow; Paul I. Musey; Christopher W. Jones; Brittney E. Punches; Meghan E. McGrath; Jose L. Pascual; Kamran Mohiuddin; Claire Pearson; David A. Peak; Robert M. Domeier; Steven E. Bruce; Niels K. Rathlev; Leon D. Sanchez; Robert H. Pietrzak; Diego A. Pizzagalli; Steven E. Harte; James Elliot; Karesten C. Koenen; Kerry J. Ressler; Samuel A. McLean; Ronald C. Kessler

doi:10.1016/J.JAD.2021.10.104

Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study

Laura T. Germine, Jutta Joormann, Eliza Passell, Lauren A. Rutter, Luke M Scheuer, Paolo Martini, Irving Hwang, Sue Lee, Nancy A. Sampson, Deanna M. Barch, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Sarah D. Linnstaedt, Tanja Jovanovic, Gari D. Clifford, Thomas C. Neylan, Scott L. RauchChristopher Lewandowski, Phyllis L. Hendry, Sophia Sheikh, Alan B. Storrow, Paul I. Musey, Christopher W. Jones, Brittney E. Punches, Meghan E. McGrath, Jose L. Pascual, Kamran Mohiuddin, Claire Pearson, David A. Peak, Robert M. Domeier, Steven E. Bruce, Niels K. Rathlev, Leon D. Sanchez, Robert H. Pietrzak, Diego A. Pizzagalli, Steven E. Harte, James Elliot, Karesten C. Koenen, Kerry J. Ressler, Samuel A. McLean, Ronald C. Kessler

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

 Background
 Previous work has indicated that differences in neurocognitive functioning may predict the development of adverse post-traumatic neuropsychiatric sequelae (APNS). Such differences may be vulnerability factors or simply correlates of APNS-related symptoms. Longitudinal studies that measure neurocognitive functioning at the time of trauma are needed to determine whether such differences precede the development of APNS.
 Methods
 Here, we present findings from a subsample of 666 ambulatory patients from the AURORA (Advancing Understanding of RecOvery afteR trumA) study. All patients presented to EDs after a motor vehicle collision (MVC). We examined associations of neurocognitive test performance shortly after MVC with peritraumatic symptoms in the ED and APNS (depression, post-traumatic stress, post-concussive symptoms, and pain) 2 weeks and 8 weeks later. Neurocognitive tests assessed processing speed, attention, verbal reasoning, memory, and social perception.
 Results
 Distress in the ED was associated with poorer processing speed and short-term memory. Poorer short-term memory was also associated with depression at 2 weeks post-MVC, even after controlling for peritraumatic distress. Finally, higher vocabulary scores were associated with pain 2 weeks post-MVC.
 Limitations
 Self-selection biases among those who present to the ED and enroll in the study limit generalizability. Also, it is not clear whether observed neurocognitive differences predate MVC exposure or arise in the immediate aftermath of MVC exposure.
 Conclusions
 Our results suggest that processing speed and short-term memory may be useful predictors of trauma-related characteristics and the development of some APNS, making such measures clinically-relevant for identifying at-risk individuals.
 

Original language	American English
Journal	Journal of Affective Disorders
Volume	298
DOIs	https://doi.org/10.1016/J.JAD.2021.10.104
State	Published - Feb 2022

Keywords

Cognition
Digital cognitive assessment
Digital neuropsychology
Longitudinal
Neuropsychology
Trauma

Disciplines

Psychiatry and Psychology

Access to Document

10.1016/J.JAD.2021.10.104License: Unspecified

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Germine, L. T., Joormann, J., Passell, E., Rutter, L. A., Scheuer, L. M., Martini, P., Hwang, I., Lee, S., Sampson, N. A., Barch, D. M., House, S. L., Beaudoin, F. L., An, X., Stevens, J. S., Zeng, D., Linnstaedt, S. D., Jovanovic, T., Clifford, G. D., Neylan, T. C., ... Kessler, R. C. (2022). Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study. Journal of Affective Disorders, 298. https://doi.org/10.1016/J.JAD.2021.10.104

Germine, LT, Joormann, J, Passell, E, Rutter, LA, Scheuer, LM, Martini, P, Hwang, I, Lee, S, Sampson, NA, Barch, DM, House, SL, Beaudoin, FL, An, X, Stevens, JS, Zeng, D, Linnstaedt, SD, Jovanovic, T, Clifford, GD, Neylan, TC, Rauch, SL, Lewandowski, C, Hendry, PL, Sheikh, S, Storrow, AB, Musey, PI, Jones, CW, Punches, BE, McGrath, ME, Pascual, JL, Mohiuddin, K, Pearson, C, Peak, DA, Domeier, RM, Bruce, SE, Rathlev, NK, Sanchez, LD, Pietrzak, RH, Pizzagalli, DA, Harte, SE, Elliot, J, Koenen, KC, Ressler, KJ, McLean, SA & Kessler, RC 2022, 'Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study', Journal of Affective Disorders, vol. 298. https://doi.org/10.1016/J.JAD.2021.10.104

@article{9289422c6f1740d7b4a941fdac230837,

title = "Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study",

abstract = " Background Previous work has indicated that differences in neurocognitive functioning may predict the development of adverse post-traumatic neuropsychiatric sequelae (APNS). Such differences may be vulnerability factors or simply correlates of APNS-related symptoms. Longitudinal studies that measure neurocognitive functioning at the time of trauma are needed to determine whether such differences precede the development of APNS. Methods Here, we present findings from a subsample of 666 ambulatory patients from the AURORA (Advancing Understanding of RecOvery afteR trumA) study. All patients presented to EDs after a motor vehicle collision (MVC). We examined associations of neurocognitive test performance shortly after MVC with peritraumatic symptoms in the ED and APNS (depression, post-traumatic stress, post-concussive symptoms, and pain) 2 weeks and 8 weeks later. Neurocognitive tests assessed processing speed, attention, verbal reasoning, memory, and social perception. Results Distress in the ED was associated with poorer processing speed and short-term memory. Poorer short-term memory was also associated with depression at 2 weeks post-MVC, even after controlling for peritraumatic distress. Finally, higher vocabulary scores were associated with pain 2 weeks post-MVC. Limitations Self-selection biases among those who present to the ED and enroll in the study limit generalizability. Also, it is not clear whether observed neurocognitive differences predate MVC exposure or arise in the immediate aftermath of MVC exposure. Conclusions Our results suggest that processing speed and short-term memory may be useful predictors of trauma-related characteristics and the development of some APNS, making such measures clinically-relevant for identifying at-risk individuals. ",

keywords = "Cognition, Digital cognitive assessment, Digital neuropsychology, Longitudinal, Neuropsychology, Trauma",

author = "Germine, {Laura T.} and Jutta Joormann and Eliza Passell and Rutter, {Lauren A.} and Scheuer, {Luke M} and Paolo Martini and Irving Hwang and Sue Lee and Sampson, {Nancy A.} and Barch, {Deanna M.} and House, {Stacey L.} and Beaudoin, {Francesca L.} and Xinming An and Stevens, {Jennifer S.} and Donglin Zeng and Linnstaedt, {Sarah D.} and Tanja Jovanovic and Clifford, {Gari D.} and Neylan, {Thomas C.} and Rauch, {Scott L.} and Christopher Lewandowski and Hendry, {Phyllis L.} and Sophia Sheikh and Storrow, {Alan B.} and Musey, {Paul I.} and Jones, {Christopher W.} and Punches, {Brittney E.} and McGrath, {Meghan E.} and Pascual, {Jose L.} and Kamran Mohiuddin and Claire Pearson and Peak, {David A.} and Domeier, {Robert M.} and Bruce, {Steven E.} and Rathlev, {Niels K.} and Sanchez, {Leon D.} and Pietrzak, {Robert H.} and Pizzagalli, {Diego A.} and Harte, {Steven E.} and James Elliot and Koenen, {Karesten C.} and Ressler, {Kerry J.} and McLean, {Samuel A.} and Kessler, {Ronald C.}",

year = "2022",

month = feb,

doi = "10.1016/J.JAD.2021.10.104",

language = "American English",

volume = "298",

journal = "Journal of Affective Disorders",

}

TY - JOUR

T1 - Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study

AU - Germine, Laura T.

AU - Joormann, Jutta

AU - Passell, Eliza

AU - Rutter, Lauren A.

AU - Scheuer, Luke M

AU - Martini, Paolo

AU - Hwang, Irving

AU - Lee, Sue

AU - Sampson, Nancy A.

AU - Barch, Deanna M.

AU - House, Stacey L.

AU - Beaudoin, Francesca L.

AU - An, Xinming

AU - Stevens, Jennifer S.

AU - Zeng, Donglin

AU - Linnstaedt, Sarah D.

AU - Jovanovic, Tanja

AU - Clifford, Gari D.

AU - Neylan, Thomas C.

AU - Rauch, Scott L.

AU - Lewandowski, Christopher

AU - Hendry, Phyllis L.

AU - Sheikh, Sophia

AU - Storrow, Alan B.

AU - Musey, Paul I.

AU - Jones, Christopher W.

AU - Punches, Brittney E.

AU - McGrath, Meghan E.

AU - Pascual, Jose L.

AU - Mohiuddin, Kamran

AU - Pearson, Claire

AU - Peak, David A.

AU - Domeier, Robert M.

AU - Bruce, Steven E.

AU - Rathlev, Niels K.

AU - Sanchez, Leon D.

AU - Pietrzak, Robert H.

AU - Pizzagalli, Diego A.

AU - Harte, Steven E.

AU - Elliot, James

AU - Koenen, Karesten C.

AU - Ressler, Kerry J.

AU - McLean, Samuel A.

AU - Kessler, Ronald C.

PY - 2022/2

Y1 - 2022/2

N2 - Background Previous work has indicated that differences in neurocognitive functioning may predict the development of adverse post-traumatic neuropsychiatric sequelae (APNS). Such differences may be vulnerability factors or simply correlates of APNS-related symptoms. Longitudinal studies that measure neurocognitive functioning at the time of trauma are needed to determine whether such differences precede the development of APNS. Methods Here, we present findings from a subsample of 666 ambulatory patients from the AURORA (Advancing Understanding of RecOvery afteR trumA) study. All patients presented to EDs after a motor vehicle collision (MVC). We examined associations of neurocognitive test performance shortly after MVC with peritraumatic symptoms in the ED and APNS (depression, post-traumatic stress, post-concussive symptoms, and pain) 2 weeks and 8 weeks later. Neurocognitive tests assessed processing speed, attention, verbal reasoning, memory, and social perception. Results Distress in the ED was associated with poorer processing speed and short-term memory. Poorer short-term memory was also associated with depression at 2 weeks post-MVC, even after controlling for peritraumatic distress. Finally, higher vocabulary scores were associated with pain 2 weeks post-MVC. Limitations Self-selection biases among those who present to the ED and enroll in the study limit generalizability. Also, it is not clear whether observed neurocognitive differences predate MVC exposure or arise in the immediate aftermath of MVC exposure. Conclusions Our results suggest that processing speed and short-term memory may be useful predictors of trauma-related characteristics and the development of some APNS, making such measures clinically-relevant for identifying at-risk individuals.

AB - Background Previous work has indicated that differences in neurocognitive functioning may predict the development of adverse post-traumatic neuropsychiatric sequelae (APNS). Such differences may be vulnerability factors or simply correlates of APNS-related symptoms. Longitudinal studies that measure neurocognitive functioning at the time of trauma are needed to determine whether such differences precede the development of APNS. Methods Here, we present findings from a subsample of 666 ambulatory patients from the AURORA (Advancing Understanding of RecOvery afteR trumA) study. All patients presented to EDs after a motor vehicle collision (MVC). We examined associations of neurocognitive test performance shortly after MVC with peritraumatic symptoms in the ED and APNS (depression, post-traumatic stress, post-concussive symptoms, and pain) 2 weeks and 8 weeks later. Neurocognitive tests assessed processing speed, attention, verbal reasoning, memory, and social perception. Results Distress in the ED was associated with poorer processing speed and short-term memory. Poorer short-term memory was also associated with depression at 2 weeks post-MVC, even after controlling for peritraumatic distress. Finally, higher vocabulary scores were associated with pain 2 weeks post-MVC. Limitations Self-selection biases among those who present to the ED and enroll in the study limit generalizability. Also, it is not clear whether observed neurocognitive differences predate MVC exposure or arise in the immediate aftermath of MVC exposure. Conclusions Our results suggest that processing speed and short-term memory may be useful predictors of trauma-related characteristics and the development of some APNS, making such measures clinically-relevant for identifying at-risk individuals.

KW - Cognition

KW - Digital cognitive assessment

KW - Digital neuropsychology

KW - Longitudinal

KW - Neuropsychology

KW - Trauma

UR - https://doi.org/10.1016/J.JAD.2021.10.104

U2 - 10.1016/J.JAD.2021.10.104

DO - 10.1016/J.JAD.2021.10.104

M3 - Article

VL - 298

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study

Abstract

Keywords

Disciplines

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