Mdm2 and MdmX Involvement in Human Cancer

Steven J. Berberich

doi:10.1007/978-94-017-9211-0_15

Mdm2 and MdmX Involvement in Human Cancer

Steven J. Berberich

University of Missouri-St. Louis

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Discovered in 1987 and 1997 respectively, Mdm2 and MdmX represent two critical cellular regulators of the p53 tumor suppressor. This chapter reviews each from initial discovery to our current understanding of their deregulation in human cancer with a focus on how each regulator impacts p53 function. While p53 independent activities of Mdm2 and MdmX are noted the reader is directed to other reviews on this topic. The chapter concludes with an examination of the various mechanisms of Mdm-deregulation and an assessment of the current therapeutic approaches to target Mdm2 and MdmX overexpression.

Original language	American English
Title of host publication	Mutant p53 and MDM2 in Cancer
DOIs	https://doi.org/10.1007/978-94-017-9211-0_15
State	Published - 2014

Keywords

Alternative splicing
E3 ligase
Gene amplification
Mdm2
MdmX
p53

Disciplines

Biochemistry, Biophysics, and Structural Biology

Access to Document

10.1007/978-94-017-9211-0_15License: Unspecified

Cite this

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title = "Mdm2 and MdmX Involvement in Human Cancer",

abstract = " Discovered in 1987 and 1997 respectively, Mdm2 and MdmX represent two critical cellular regulators of the p53 tumor suppressor. This chapter reviews each from initial discovery to our current understanding of their deregulation in human cancer with a focus on how each regulator impacts p53 function. While p53 independent activities of Mdm2 and MdmX are noted the reader is directed to other reviews on this topic. The chapter concludes with an examination of the various mechanisms of Mdm-deregulation and an assessment of the current therapeutic approaches to target Mdm2 and MdmX overexpression. ",

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N2 - Discovered in 1987 and 1997 respectively, Mdm2 and MdmX represent two critical cellular regulators of the p53 tumor suppressor. This chapter reviews each from initial discovery to our current understanding of their deregulation in human cancer with a focus on how each regulator impacts p53 function. While p53 independent activities of Mdm2 and MdmX are noted the reader is directed to other reviews on this topic. The chapter concludes with an examination of the various mechanisms of Mdm-deregulation and an assessment of the current therapeutic approaches to target Mdm2 and MdmX overexpression.

AB - Discovered in 1987 and 1997 respectively, Mdm2 and MdmX represent two critical cellular regulators of the p53 tumor suppressor. This chapter reviews each from initial discovery to our current understanding of their deregulation in human cancer with a focus on how each regulator impacts p53 function. While p53 independent activities of Mdm2 and MdmX are noted the reader is directed to other reviews on this topic. The chapter concludes with an examination of the various mechanisms of Mdm-deregulation and an assessment of the current therapeutic approaches to target Mdm2 and MdmX overexpression.

KW - Alternative splicing

KW - E3 ligase

KW - Gene amplification

KW - Mdm2

KW - MdmX

KW - p53

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M3 - Chapter

BT - Mutant p53 and MDM2 in Cancer

ER -

Mdm2 and MdmX Involvement in Human Cancer

Abstract

Keywords

Disciplines

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