Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

TY - JOUR

T1 - Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

AU - Bashkin, James K

AU - Castaneda, C H

AU - Scuderi, Maria J

AU - Edwards, T J

AU - Harris, G D

AU - Dupureur, Cynthia M.

AU - Koeller, Kevin J.

AU - Fisher, Christopher

AU - Edwards, T. G.

N1 - We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.

PY - 2016/1/1

Y1 - 2016/1/1

UR - https://pubs.rsc.org/en/content/articlelanding/2016/MD/C6MD00371K#!divAbstract

UR - http://pubs.rsc.org/en/content/articlelanding/2016/md/c6md00371k#!divAbstract

U2 - 10.1039/C6MD00371K

DO - 10.1039/C6MD00371K

M3 - Article

VL - 7

JO - MedChemComm

JF - MedChemComm

ER -