Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

James K Bashkin; C H Castaneda; Maria J Scuderi; T J Edwards; G D Harris; Cynthia M. Dupureur; Kevin J. Koeller; Christopher Fisher; T. G. Edwards

doi:10.1039/C6MD00371K

Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

James K Bashkin, C H Castaneda, Maria J Scuderi, T J Edwards, G D Harris, Cynthia M. Dupureur, Kevin J. Koeller, Christopher Fisher, T. G. Edwards

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	MedChemComm
Volume	7
DOIs	https://doi.org/10.1039/C6MD00371K
State	Published - Jan 1 2016

Disciplines

Physical Sciences and Mathematics
Chemistry
Organic Chemistry
Biochemistry

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10.1039/C6MD00371KLicense: Unspecified

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@article{1ff37271852b488b956fa5769eeb5e3c,

title = "Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution",

author = "Bashkin, {James K} and Castaneda, {C H} and Scuderi, {Maria J} and Edwards, {T J} and Harris, {G D} and Dupureur, {Cynthia M.} and Koeller, {Kevin J.} and Christopher Fisher and Edwards, {T. G.}",

note = "We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.",

year = "2016",

month = jan,

day = "1",

doi = "10.1039/C6MD00371K",

language = "American English",

volume = "7",

journal = "MedChemComm",

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TY - JOUR

T1 - Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

AU - Bashkin, James K

AU - Castaneda, C H

AU - Scuderi, Maria J

AU - Edwards, T J

AU - Harris, G D

AU - Dupureur, Cynthia M.

AU - Koeller, Kevin J.

AU - Fisher, Christopher

AU - Edwards, T. G.

N1 - We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.

PY - 2016/1/1

Y1 - 2016/1/1

UR - https://pubs.rsc.org/en/content/articlelanding/2016/MD/C6MD00371K#!divAbstract

UR - http://pubs.rsc.org/en/content/articlelanding/2016/md/c6md00371k#!divAbstract

U2 - 10.1039/C6MD00371K

DO - 10.1039/C6MD00371K

M3 - Article

VL - 7

JO - MedChemComm

JF - MedChemComm

ER -

Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

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