High-Throughput 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library

Bruce Hamper; David M. Snyderman; Thomas J. Owen; Angela M. Scates; Dennis C. Owsley; Allen S. Kesselring; Robert C. Chott

High-Throughput 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library

Bruce Hamper, David M. Snyderman, Thomas J. Owen, Angela M. Scates, Dennis C. Owsley, Allen S. Kesselring, Robert C. Chott

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Combinatorial Chemistry
Volume	1
State	Published - Jan 23 1999

Disciplines

Physical Sciences and Mathematics
Chemistry

Cite this

@article{8894bf25959d4381b49d8e0aa31fca46,

title = "High-Throughput 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library",

author = "Bruce Hamper and Snyderman, {David M.} and Owen, {Thomas J.} and Scates, {Angela M.} and Owsley, {Dennis C.} and Kesselring, {Allen S.} and Chott, {Robert C.}",

note = "A solid phase organic synthesis method has been developed for the preparation of substituted methylene malonamic acids and malonic ester mono acids 5. Two substituents are introduced into the core molecule 5 by preparation of unsymmetrical malonic acid derivatives 2, followed by Knoevenagel condensation with aromatic or aliphatic aldehydes, giving resin-bound 4.",

year = "1999",

month = jan,

day = "23",

language = "American English",

volume = "1",

journal = "Journal of Combinatorial Chemistry",

}

TY - JOUR

T1 - High-Throughput 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library

AU - Hamper, Bruce

AU - Snyderman, David M.

AU - Owen, Thomas J.

AU - Scates, Angela M.

AU - Owsley, Dennis C.

AU - Kesselring, Allen S.

AU - Chott, Robert C.

N1 - A solid phase organic synthesis method has been developed for the preparation of substituted methylene malonamic acids and malonic ester mono acids 5. Two substituents are introduced into the core molecule 5 by preparation of unsymmetrical malonic acid derivatives 2, followed by Knoevenagel condensation with aromatic or aliphatic aldehydes, giving resin-bound 4.

PY - 1999/1/23

Y1 - 1999/1/23

UR - https://doi.org/10.1021/cc9800172

M3 - Article

VL - 1

JO - Journal of Combinatorial Chemistry

JF - Journal of Combinatorial Chemistry

ER -

High-Throughput 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library

Disciplines

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