Fenofibric acid

Nigam Rath; W. Haq; G K Balendiran

doi:10.1107/S0108270104032573

Fenofibric acid

Nigam Rath, W. Haq, G K Balendiran

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

Unlike the related fenofibrate molecule [Henry, Zhang, Gao & Bruckner (2003). Acta Cryst . E 59 , o699-o700], fenofibric acid {systematic name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid}, C 17 H 15 ClO 4 , contains a carboxylic acid moiety instead of an ester moiety. This polar moiety plays an important role in the formation of a rare acid-to-ketone hydrogen-bond-type packing interaction. The lack of an isopropyl group in fenofibric acid aligns the carboxyl group on the same side as the ketone carbonyl group; this conformation may play an important role in discrimination between the acid and the fenofibrate molecule in molecular recognition.

Original language	American English
Journal	Acta Crystallographica
Volume	61
DOIs	https://doi.org/10.1107/S0108270104032573
State	Published - 2005

Disciplines

Life Sciences
Biochemistry, Biophysics, and Structural Biology
Biochemistry

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title = "Fenofibric acid",

abstract = " Unlike the related fenofibrate molecule [Henry, Zhang, Gao & Bruckner (2003). Acta Cryst . E 59 , o699-o700], fenofibric acid {systematic name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid}, C 17 H 15 ClO 4 , contains a carboxylic acid moiety instead of an ester moiety. This polar moiety plays an important role in the formation of a rare acid-to-ketone hydrogen-bond-type packing interaction. The lack of an isopropyl group in fenofibric acid aligns the carboxyl group on the same side as the ketone carbonyl group; this conformation may play an important role in discrimination between the acid and the fenofibrate molecule in molecular recognition. ",

author = "Nigam Rath and W. Haq and Balendiran, {G K}",

year = "2005",

doi = "10.1107/S0108270104032573",

language = "American English",

volume = "61",

journal = "Acta Crystallographica",

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TY - JOUR

T1 - Fenofibric acid

AU - Rath, Nigam

AU - Haq, W.

AU - Balendiran, G K

PY - 2005

Y1 - 2005

N2 - Unlike the related fenofibrate molecule [Henry, Zhang, Gao & Bruckner (2003). Acta Cryst . E 59 , o699-o700], fenofibric acid {systematic name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid}, C 17 H 15 ClO 4 , contains a carboxylic acid moiety instead of an ester moiety. This polar moiety plays an important role in the formation of a rare acid-to-ketone hydrogen-bond-type packing interaction. The lack of an isopropyl group in fenofibric acid aligns the carboxyl group on the same side as the ketone carbonyl group; this conformation may play an important role in discrimination between the acid and the fenofibrate molecule in molecular recognition.

AB - Unlike the related fenofibrate molecule [Henry, Zhang, Gao & Bruckner (2003). Acta Cryst . E 59 , o699-o700], fenofibric acid {systematic name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid}, C 17 H 15 ClO 4 , contains a carboxylic acid moiety instead of an ester moiety. This polar moiety plays an important role in the formation of a rare acid-to-ketone hydrogen-bond-type packing interaction. The lack of an isopropyl group in fenofibric acid aligns the carboxyl group on the same side as the ketone carbonyl group; this conformation may play an important role in discrimination between the acid and the fenofibrate molecule in molecular recognition.

UR - https://doi.org/10.1107/S0108270104032573

U2 - 10.1107/S0108270104032573

DO - 10.1107/S0108270104032573

M3 - Article

VL - 61

JO - Acta Crystallographica

JF - Acta Crystallographica

ER -

Fenofibric acid

Abstract

Disciplines

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