Efficient new ribozyme mimics: direct mapping of molecular design principles from small molecules to macromolecular, biomimetic catalysts.

William C. Putnam; Andrew T. Daniher; Bobby N. Trawick; James K. Bashkin

doi:10.1093/nar/29.10.2199

Efficient new ribozyme mimics: direct mapping of molecular design principles from small molecules to macromolecular, biomimetic catalysts.

William C. Putnam, Andrew T. Daniher, Bobby N. Trawick, James K. Bashkin

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Nucleic Acids Research
Volume	29
DOIs	https://doi.org/10.1093/nar/29.10.2199
State	Published - May 15 2001
Externally published	Yes

Disciplines

Biochemistry
Chemistry
Biology
Molecular Biology

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10.1093/nar/29.10.2199License: Unspecified

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@article{904100c9754d4ddf843af1ad16d94166,

title = "Efficient new ribozyme mimics: direct mapping of molecular design principles from small molecules to macromolecular, biomimetic catalysts.",

author = "Putnam, \{William C.\} and Daniher, \{Andrew T.\} and Trawick, \{Bobby N.\} and Bashkin, \{James K.\}",

note = "Dramatic improvements in ribozyme mimics have been achieved by employing the principles of small molecule catalysis to the design of macromolecular, biomimetic reagents. Ribozyme mimics derived from the ligand 2,9-dimethylphenanthroline (neocuproine) show at least 30-fold improvements in efficiency at sequence-specific RNA cleavage when compared with analogous o-phenanthroline- and terpyridine-derived reagents.",

year = "2001",

month = may,

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doi = "10.1093/nar/29.10.2199",

language = "American English",

volume = "29",

journal = "Nucleic Acids Research",

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T1 - Efficient new ribozyme mimics: direct mapping of molecular design principles from small molecules to macromolecular, biomimetic catalysts.

AU - Putnam, William C.

AU - Daniher, Andrew T.

AU - Trawick, Bobby N.

AU - Bashkin, James K.

N1 - Dramatic improvements in ribozyme mimics have been achieved by employing the principles of small molecule catalysis to the design of macromolecular, biomimetic reagents. Ribozyme mimics derived from the ligand 2,9-dimethylphenanthroline (neocuproine) show at least 30-fold improvements in efficiency at sequence-specific RNA cleavage when compared with analogous o-phenanthroline- and terpyridine-derived reagents.

PY - 2001/5/15

Y1 - 2001/5/15

UR - https://academic.oup.com/nar/article/29/10/2199/2383922

U2 - 10.1093/nar/29.10.2199

DO - 10.1093/nar/29.10.2199

M3 - Article

VL - 29

JO - Nucleic Acids Research

JF - Nucleic Acids Research

ER -

Efficient new ribozyme mimics: direct mapping of molecular design principles from small molecules to macromolecular, biomimetic catalysts.

Disciplines

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