Does Physiologic Response to Loud Tones Change Following Cognitive-behavioral Treatment for Posttraumatic Stress Disorder?

This study examined responses to loud tones before and after cognitive–behavioral treatment for posttraumatic stress disorder (PTSD). Seventy-four women in a PTSD treatment outcome study for rape-related ( n  = 54) or physical assault-related PTSD ( n  = 20) were assessed in an auditory loud tone paradigm. Assessments were conducted before and after a 6-week period of cognitive–behavioral therapy. Physiologic responses to loud tones included heart rate (HR), skin conductance (SC), and eye-blink electromyogram (EMG). Groups were formed based upon treatment outcome and included a treatment responder group (no PTSD at posttreatment) and a nonresponder group (PTSD-positive at posttreatment). Treatment was successful for 53 of 74 women (72%) and unsuccessful for 21 women (28%). Responders and nonresponders were not significantly different from each other at pretreatment on the main outcome variables. Treatment responders showed a significant reduction in loud tone-related EMG, HR, and SC responses from pre- to posttreatment (partial  η 2  = .243, .308, and .365, respectively; all  p  < .001) and the EMG and HR responses were significantly smaller than nonresponders at posttreatment (partial  η 2 2 = .107,  p  = .004 and .193,  p  < .001, respectively). Successful cognitive–behavioral treatment of PTSD is associated with a quantifiable reduction in physiological responding to loud tones.