Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Bruce Hamper; Mark E. Schnute; Patrick M. O’Brien; Joe Nahra; Mark Morris; W. Howard Roark; Cathleen E. Hanau; Peter G. Ruminski; Jeffrey A. Scholten; Theresa R. Fletcher

doi:10.1016/j.bmcl.2009.11.081

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Bruce Hamper
, Mark E. Schnute
, Patrick M. O’Brien
, Joe Nahra
, Mark Morris
, W. Howard Roark
, Cathleen E. Hanau
, Peter G. Ruminski
, Jeffrey A. Scholten
, Theresa R. Fletcher

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	20
DOIs	https://doi.org/10.1016/j.bmcl.2009.11.081
State	Published - Jan 15 2010

Disciplines

Physical Sciences and Mathematics
Chemistry

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Hamper, B., Schnute, M. E., O’Brien, P. M., Nahra, J., Morris, M., Roark, W. H., Hanau, C. E., Ruminski, P. G., Scholten, J. A., & Fletcher, T. R. (2010). Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorganic & Medicinal Chemistry Letters, 20. https://doi.org/10.1016/j.bmcl.2009.11.081

Hamper, B, Schnute, ME, O’Brien, PM, Nahra, J, Morris, M, Roark, WH, Hanau, CE, Ruminski, PG, Scholten, JA & Fletcher, TR 2010, 'Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis', Bioorganic & Medicinal Chemistry Letters, vol. 20. https://doi.org/10.1016/j.bmcl.2009.11.081

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title = "Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis",

author = "Bruce Hamper and Schnute, \{Mark E.\} and O{\textquoteright}Brien, \{Patrick M.\} and Joe Nahra and Mark Morris and Roark, \{W. Howard\} and Hanau, \{Cathleen E.\} and Ruminski, \{Peter G.\} and Scholten, \{Jeffrey A.\} and Fletcher, \{Theresa R.\}",

year = "2010",

month = jan,

day = "15",

doi = "10.1016/j.bmcl.2009.11.081",

language = "American English",

volume = "20",

journal = "Bioorganic \& Medicinal Chemistry Letters",

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T1 - Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

AU - Hamper, Bruce

AU - Schnute, Mark E.

AU - O’Brien, Patrick M.

AU - Nahra, Joe

AU - Morris, Mark

AU - Roark, W. Howard

AU - Hanau, Cathleen E.

AU - Ruminski, Peter G.

AU - Scholten, Jeffrey A.

AU - Fletcher, Theresa R.

PY - 2010/1/15

Y1 - 2010/1/15

UR - https://www-sciencedirect-com.proxy.mul.missouri.edu/science/article/pii/S0960894X09016515?via%3Dihub

U2 - 10.1016/j.bmcl.2009.11.081

DO - 10.1016/j.bmcl.2009.11.081

M3 - Article

VL - 20

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

ER -

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

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