Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Bruce Hamper; Mark E. Schnute; Patrick M. O’Brien; Joe Nahra; Mark Morris; W. Howard Roark; Cathleen E. Hanau; Peter G. Ruminski; Jeffrey A. Scholten; Theresa R. Fletcher

doi:10.1016/j.bmcl.2009.11.081

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Bruce Hamper, Mark E. Schnute, Patrick M. O’Brien, Joe Nahra, Mark Morris, W. Howard Roark, Cathleen E. Hanau, Peter G. Ruminski, Jeffrey A. Scholten, Theresa R. Fletcher

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	20
DOIs	https://doi.org/10.1016/j.bmcl.2009.11.081
State	Published - Jan 15 2010

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Physical Sciences and Mathematics
Chemistry

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Hamper, B., Schnute, M. E., O’Brien, P. M., Nahra, J., Morris, M., Roark, W. H., Hanau, C. E., Ruminski, P. G., Scholten, J. A., & Fletcher, T. R. (2010). Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorganic & Medicinal Chemistry Letters, 20. https://doi.org/10.1016/j.bmcl.2009.11.081

Hamper, B, Schnute, ME, O’Brien, PM, Nahra, J, Morris, M, Roark, WH, Hanau, CE, Ruminski, PG, Scholten, JA & Fletcher, TR 2010, 'Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis', Bioorganic & Medicinal Chemistry Letters, vol. 20. https://doi.org/10.1016/j.bmcl.2009.11.081

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title = "Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis",

author = "Bruce Hamper and Schnute, {Mark E.} and O{\textquoteright}Brien, {Patrick M.} and Joe Nahra and Mark Morris and Roark, {W. Howard} and Hanau, {Cathleen E.} and Ruminski, {Peter G.} and Scholten, {Jeffrey A.} and Fletcher, {Theresa R.}",

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T1 - Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

AU - Hamper, Bruce

AU - Schnute, Mark E.

AU - O’Brien, Patrick M.

AU - Nahra, Joe

AU - Morris, Mark

AU - Roark, W. Howard

AU - Hanau, Cathleen E.

AU - Ruminski, Peter G.

AU - Scholten, Jeffrey A.

AU - Fletcher, Theresa R.

PY - 2010/1/15

Y1 - 2010/1/15

UR - https://www-sciencedirect-com.proxy.mul.missouri.edu/science/article/pii/S0960894X09016515?via%3Dihub

U2 - 10.1016/j.bmcl.2009.11.081

DO - 10.1016/j.bmcl.2009.11.081

M3 - Article

VL - 20

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

ER -

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

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