Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

Chris P. Carron; John I. Trujillo; Kirk L. Olson; Wei Huang; Bruce C. Hamper; Tom Dice; Bradley E. Neal; Matthew J. Pelc; Jacqueline E. Day; Douglas C. Rohrer; James R. Kiefer; Joseph B. Moon; Barbara A. Schweitzer; Tanisha D. Blake; Steve R. Turner; Rhonda Woerndle; Brenda L. Case; Christine P. Bono; Vickie M. Dilworth; Christie L. Funckes-Shippy; Becky L. Hood; Gina M. Jerome; Christine M. Kornmeier; Melissa R. Radabaugh; Melanie L. Williams; Michael S. Davies; Craig D. Wegner; Dean J. Welsch; William M. Abraham; Chad J. Warren; Martin E. Dowty; Fengmei Hua; Anup Zutshi; Jerry Z. Yang; Atli Thorarensen

doi:10.1021/ml900025z

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

Chris P. Carron, John I. Trujillo, Kirk L. Olson, Wei Huang, Bruce C. Hamper, Tom Dice, Bradley E. Neal, Matthew J. Pelc, Jacqueline E. Day, Douglas C. Rohrer, James R. Kiefer, Joseph B. Moon, Barbara A. Schweitzer, Tanisha D. Blake, Steve R. Turner, Rhonda Woerndle, Brenda L. Case, Christine P. Bono, Vickie M. Dilworth, Christie L. Funckes-ShippyBecky L. Hood, Gina M. Jerome, Christine M. Kornmeier, Melissa R. Radabaugh, Melanie L. Williams, Michael S. Davies, Craig D. Wegner, Dean J. Welsch, William M. Abraham, Chad J. Warren, Martin E. Dowty, Fengmei Hua, Anup Zutshi, Jerry Z. Yang, Atli Thorarensen

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	ACS Medicinal Chemistry Letters
Volume	1
DOIs	https://doi.org/10.1021/ml900025z
State	Published - May 13 2010

Keywords

Hematopoietic prostaglandin D synthase (HPGDS)
PGH2
PGD2
airway allergy
inflammatory processes
cyclooxygenase (COX)

Disciplines

Biology
Pharmacology
Biochemistry
Immunology and Infectious Disease

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Carron, C. P., Trujillo, J. I., Olson, K. L., Huang, W., Hamper, B. C., Dice, T., Neal, B. E., Pelc, M. J., Day, J. E., Rohrer, D. C., Kiefer, J. R., Moon, J. B., Schweitzer, B. A., Blake, T. D., Turner, S. R., Woerndle, R., Case, B. L., Bono, C. P., Dilworth, V. M., ... Thorarensen, A. (2010). Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Medicinal Chemistry Letters, 1. https://doi.org/10.1021/ml900025z

Carron, CP, Trujillo, JI, Olson, KL, Huang, W, Hamper, BC, Dice, T, Neal, BE, Pelc, MJ, Day, JE, Rohrer, DC, Kiefer, JR, Moon, JB, Schweitzer, BA, Blake, TD, Turner, SR, Woerndle, R, Case, BL, Bono, CP, Dilworth, VM, Funckes-Shippy, CL, Hood, BL, Jerome, GM, Kornmeier, CM, Radabaugh, MR, Williams, ML, Davies, MS, Wegner, CD, Welsch, DJ, Abraham, WM, Warren, CJ, Dowty, ME, Hua, F, Zutshi, A, Yang, JZ & Thorarensen, A 2010, 'Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)', ACS Medicinal Chemistry Letters, vol. 1. https://doi.org/10.1021/ml900025z

@article{c98f5a6eaa664967a370e190c0a9186c,

title = "Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)",

keywords = "Hematopoietic prostaglandin D synthase (HPGDS), PGH2, PGD2, airway allergy, inflammatory processes, cyclooxygenase (COX)",

author = "Carron, \{Chris P.\} and Trujillo, \{John I.\} and Olson, \{Kirk L.\} and Wei Huang and Hamper, \{Bruce C.\} and Tom Dice and Neal, \{Bradley E.\} and Pelc, \{Matthew J.\} and Day, \{Jacqueline E.\} and Rohrer, \{Douglas C.\} and Kiefer, \{James R.\} and Moon, \{Joseph B.\} and Schweitzer, \{Barbara A.\} and Blake, \{Tanisha D.\} and Turner, \{Steve R.\} and Rhonda Woerndle and Case, \{Brenda L.\} and Bono, \{Christine P.\} and Dilworth, \{Vickie M.\} and Funckes-Shippy, \{Christie L.\} and Hood, \{Becky L.\} and Jerome, \{Gina M.\} and Kornmeier, \{Christine M.\} and Radabaugh, \{Melissa R.\} and Williams, \{Melanie L.\} and Davies, \{Michael S.\} and Wegner, \{Craig D.\} and Welsch, \{Dean J.\} and Abraham, \{William M.\} and Warren, \{Chad J.\} and Dowty, \{Martin E.\} and Fengmei Hua and Anup Zutshi and Yang, \{Jerry Z.\} and Atli Thorarensen",

note = "Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH 2 into PGD 2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.",

year = "2010",

month = may,

day = "13",

doi = "10.1021/ml900025z",

language = "American English",

volume = "1",

journal = "ACS Medicinal Chemistry Letters",

}

TY - JOUR

T1 - Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

AU - Carron, Chris P.

AU - Trujillo, John I.

AU - Olson, Kirk L.

AU - Huang, Wei

AU - Hamper, Bruce C.

AU - Dice, Tom

AU - Neal, Bradley E.

AU - Pelc, Matthew J.

AU - Day, Jacqueline E.

AU - Rohrer, Douglas C.

AU - Kiefer, James R.

AU - Moon, Joseph B.

AU - Schweitzer, Barbara A.

AU - Blake, Tanisha D.

AU - Turner, Steve R.

AU - Woerndle, Rhonda

AU - Case, Brenda L.

AU - Bono, Christine P.

AU - Dilworth, Vickie M.

AU - Funckes-Shippy, Christie L.

AU - Hood, Becky L.

AU - Jerome, Gina M.

AU - Kornmeier, Christine M.

AU - Radabaugh, Melissa R.

AU - Williams, Melanie L.

AU - Davies, Michael S.

AU - Wegner, Craig D.

AU - Welsch, Dean J.

AU - Abraham, William M.

AU - Warren, Chad J.

AU - Dowty, Martin E.

AU - Hua, Fengmei

AU - Zutshi, Anup

AU - Yang, Jerry Z.

AU - Thorarensen, Atli

N1 - Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH 2 into PGD 2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.

PY - 2010/5/13

Y1 - 2010/5/13

KW - Hematopoietic prostaglandin D synthase (HPGDS)

KW - PGH2

KW - PGD2

KW - airway allergy

KW - inflammatory processes

KW - cyclooxygenase (COX)

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007851/

U2 - 10.1021/ml900025z

DO - 10.1021/ml900025z

M3 - Article

VL - 1

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

ER -

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

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