@article{c98f5a6eaa664967a370e190c0a9186c,
title = "Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)",
keywords = "Hematopoietic prostaglandin D synthase (HPGDS), PGH2, PGD2, airway allergy, inflammatory processes, cyclooxygenase (COX)",
author = "Carron, {Chris P.} and Trujillo, {John I.} and Olson, {Kirk L.} and Wei Huang and Hamper, {Bruce C.} and Tom Dice and Neal, {Bradley E.} and Pelc, {Matthew J.} and Day, {Jacqueline E.} and Rohrer, {Douglas C.} and Kiefer, {James R.} and Moon, {Joseph B.} and Schweitzer, {Barbara A.} and Blake, {Tanisha D.} and Turner, {Steve R.} and Rhonda Woerndle and Case, {Brenda L.} and Bono, {Christine P.} and Dilworth, {Vickie M.} and Funckes-Shippy, {Christie L.} and Hood, {Becky L.} and Jerome, {Gina M.} and Kornmeier, {Christine M.} and Radabaugh, {Melissa R.} and Williams, {Melanie L.} and Davies, {Michael S.} and Wegner, {Craig D.} and Welsch, {Dean J.} and Abraham, {William M.} and Warren, {Chad J.} and Dowty, {Martin E.} and Fengmei Hua and Anup Zutshi and Yang, {Jerry Z.} and Atli Thorarensen",
note = "Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH 2 into PGD 2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.",
year = "2010",
month = may,
day = "13",
doi = "10.1021/ml900025z",
language = "American English",
volume = "1",
journal = "ACS Medicinal Chemistry Letters",
}