TY - JOUR
T1 - Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
AU - Stevens, Jennifer
AU - Harnett, Nathaniel G.
AU - Lebois, Lauren A. M.
AU - van Rooij, Sanne J.H.
AU - Ely, Timothy D.
AU - Roeckner, Alyssa
AU - Vincent, Nico
AU - Beaudoin, Francesca L.
AU - An, Xinming
AU - Zeng, Donglin
AU - Neylan, Thomas C.
AU - Clifford, Gari D.
AU - Linnstaedt, Sarah D.
AU - Germine, Laura T.
AU - Rauch, Scott L.
AU - Lewandowski, Christopher
AU - Storrow, Alan B.
AU - Hendry, Phyllis L.
AU - Sheikh, Sophia
AU - Musey Jr., Paul I.
AU - Haran, John P.
AU - Jones, Christopher W.
AU - Punches, Brittany E.
AU - Lyons, Michael S.
AU - Kurz, Michael C.
AU - McGrath, Meghan E.
AU - Pascual, Jose L.
AU - Datner, Elizabeth M.
AU - Chang, Anna Marie
AU - Pearson, Claire
AU - Peak, David A.
AU - Domeier, Robert M.
AU - O’Neil, Brian J.
AU - Rathlev, Niels K.
AU - Harte, Steven E.
AU - Elliot, James
AU - Murty, Vishnu P.
AU - Jovanovic, Tanja
AU - Bruce, Steven
AU - House, Stacey L.
AU - Kessler, Ronald C.
AU - Koenen, Karestan C.
AU - McLean, Samuel A.
AU - Ressler, Kerry J.
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PY - 2021/11
Y1 - 2021/11
N2 - Objective: Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations. Methods: A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments. Results: Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms. Conclusions: These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.
AB - Objective: Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations. Methods: A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments. Results: Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms. Conclusions: These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.
UR - https://doi.org/10.1176/APPI.AJP.2021.20101526
U2 - 10.1176/APPI.AJP.2021.20101526
DO - 10.1176/APPI.AJP.2021.20101526
M3 - Article
VL - 178
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
ER -