Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries

Philip Moons; Koen Luyckx; Corina Thomet; Werner Budts; Junko Enomoto; Maayke A Sluman; Chun-Wei Lu; Jamie L Jackson; Paul Khairy; Stephen Cook; Shanthi Chidambarathanu; Luis E Alday; Katrine Eriksen; Mikael G Dellborg; Malin Berghammer; Bengt Johansson; Andrew Mackie; Samuel Menahem; Maryanne Caruana; Gruschen Veldtman; Alexandra Soufi; Susan M Fernandes; Kamila White; Edward Callus; Shelby Kutty; Fouke Ombelet; Silke Apers; Adrienne Kovacs

Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries

Philip Moons, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke A Sluman, Chun-Wei Lu, Jamie L Jackson, Paul Khairy, Stephen Cook, Shanthi Chidambarathanu, Luis E Alday, Katrine Eriksen, Mikael G Dellborg, Malin Berghammer, Bengt Johansson, Andrew Mackie, Samuel Menahem, Maryanne Caruana, Gruschen VeldtmanAlexandra Soufi, Susan M Fernandes, Kamila White, Edward Callus, Shelby Kutty, Fouke Ombelet, Silke Apers, Adrienne Kovacs

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

 Objectives: Higher complexity of congenital heart defects (CHD) is found to be associated with poorer physical functioning and quality of life (QOL). Within complexity categories, there may be a large variation in outcomes as well, according to the type of CHD. However, prior research is hampered by limited sample sizes. Therefore, we sought to compare the physical functioning and QOL in different CHD from a large international sample.
 Methods: In a cross-sectional study, we enrolled 4,028 adult CHD patients from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3,589 patients (median age=32y; 53% women). Physical functioning was measured using the Physical Component Summary (PCS) of the SF-12 (range 0-100). A linear analog scale was used to measure QOL, ranging from 0 (worst QOL) to 100 (best QOL). Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and physical functioning and QOL, adjusted for New York Heart Association (NYHA) class and other patient characteristics, and with country as random effect.
 Results: Patients with coarctation of the aorta reported the highest score on PCS (83.6±17.2) and patients with isolated aortic valve disease had the highest QOL (82.0±13.8) (Fig 1). Patients with cyanotic heart disease or Eisenmenger syndrome showed the lowest scores both on PCS (53.5±21.8) and QOL (67.1±21.8). When taking the CHD with the highest score as reference, the PCS was significantly lower in patients with repaired ductus arteriosus/ASD/VSD, transposition of the great arteries, pulmonary atresia, Marfan, and cyanotic heart disease/Eisenmenger syndrome. For QOL, no differences were found for the types of CHD, when adjusted for other patient characteristics.
 Conclusions: Some types of CHD predict worse physical functioning, above and beyond NYHA class and other patient characteristics. CHD type was not found to be an independent predictor for QOL.

Original language	American English
Journal	Circulation
State	Published - Nov 19 2019

Disciplines

Endocrinology, Diabetes, and Metabolism
Critical Care
Cardiology
Internal Medicine
Medicine and Health Sciences

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Moons, P., Luyckx, K., Thomet, C., Budts, W., Enomoto, J., Sluman, M. A., Lu, C.-W., Jackson, J. L., Khairy, P., Cook, S., Chidambarathanu, S., Alday, L. E., Eriksen, K., Dellborg, M. G., Berghammer, M., Johansson, B., Mackie, A., Menahem, S., Caruana, M., ... Kovacs, A. (2019). Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries. Circulation.

Moons, P, Luyckx, K, Thomet, C, Budts, W, Enomoto, J, Sluman, MA, Lu, C-W, Jackson, JL, Khairy, P, Cook, S, Chidambarathanu, S, Alday, LE, Eriksen, K, Dellborg, MG, Berghammer, M, Johansson, B, Mackie, A, Menahem, S, Caruana, M, Veldtman, G, Soufi, A, Fernandes, SM, White, K, Callus, E, Kutty, S, Ombelet, F, Apers, S & Kovacs, A 2019, 'Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries', Circulation.

@article{14398e263ee049ebba33249a0794b796,

title = "Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries",

abstract = " Objectives: Higher complexity of congenital heart defects (CHD) is found to be associated with poorer physical functioning and quality of life (QOL). Within complexity categories, there may be a large variation in outcomes as well, according to the type of CHD. However, prior research is hampered by limited sample sizes. Therefore, we sought to compare the physical functioning and QOL in different CHD from a large international sample. Methods: In a cross-sectional study, we enrolled 4,028 adult CHD patients from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3,589 patients (median age=32y; 53% women). Physical functioning was measured using the Physical Component Summary (PCS) of the SF-12 (range 0-100). A linear analog scale was used to measure QOL, ranging from 0 (worst QOL) to 100 (best QOL). Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and physical functioning and QOL, adjusted for New York Heart Association (NYHA) class and other patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta reported the highest score on PCS (83.6±17.2) and patients with isolated aortic valve disease had the highest QOL (82.0±13.8) (Fig 1). Patients with cyanotic heart disease or Eisenmenger syndrome showed the lowest scores both on PCS (53.5±21.8) and QOL (67.1±21.8). When taking the CHD with the highest score as reference, the PCS was significantly lower in patients with repaired ductus arteriosus/ASD/VSD, transposition of the great arteries, pulmonary atresia, Marfan, and cyanotic heart disease/Eisenmenger syndrome. For QOL, no differences were found for the types of CHD, when adjusted for other patient characteristics. Conclusions: Some types of CHD predict worse physical functioning, above and beyond NYHA class and other patient characteristics. CHD type was not found to be an independent predictor for QOL.",

author = "Philip Moons and Koen Luyckx and Corina Thomet and Werner Budts and Junko Enomoto and Sluman, {Maayke A} and Chun-Wei Lu and Jackson, {Jamie L} and Paul Khairy and Stephen Cook and Shanthi Chidambarathanu and Alday, {Luis E} and Katrine Eriksen and Dellborg, {Mikael G} and Malin Berghammer and Bengt Johansson and Andrew Mackie and Samuel Menahem and Maryanne Caruana and Gruschen Veldtman and Alexandra Soufi and Fernandes, {Susan M} and Kamila White and Edward Callus and Shelby Kutty and Fouke Ombelet and Silke Apers and Adrienne Kovacs",

year = "2019",

month = nov,

day = "19",

language = "American English",

journal = "Circulation",

}

TY - JOUR

T1 - Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries

AU - Moons, Philip

AU - Luyckx, Koen

AU - Thomet, Corina

AU - Budts, Werner

AU - Enomoto, Junko

AU - Sluman, Maayke A

AU - Lu, Chun-Wei

AU - Jackson, Jamie L

AU - Khairy, Paul

AU - Cook, Stephen

AU - Chidambarathanu, Shanthi

AU - Alday, Luis E

AU - Eriksen, Katrine

AU - Dellborg, Mikael G

AU - Berghammer, Malin

AU - Johansson, Bengt

AU - Mackie, Andrew

AU - Menahem, Samuel

AU - Caruana, Maryanne

AU - Veldtman, Gruschen

AU - Soufi, Alexandra

AU - Fernandes, Susan M

AU - White, Kamila

AU - Callus, Edward

AU - Kutty, Shelby

AU - Ombelet, Fouke

AU - Apers, Silke

AU - Kovacs, Adrienne

PY - 2019/11/19

Y1 - 2019/11/19

N2 - Objectives: Higher complexity of congenital heart defects (CHD) is found to be associated with poorer physical functioning and quality of life (QOL). Within complexity categories, there may be a large variation in outcomes as well, according to the type of CHD. However, prior research is hampered by limited sample sizes. Therefore, we sought to compare the physical functioning and QOL in different CHD from a large international sample. Methods: In a cross-sectional study, we enrolled 4,028 adult CHD patients from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3,589 patients (median age=32y; 53% women). Physical functioning was measured using the Physical Component Summary (PCS) of the SF-12 (range 0-100). A linear analog scale was used to measure QOL, ranging from 0 (worst QOL) to 100 (best QOL). Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and physical functioning and QOL, adjusted for New York Heart Association (NYHA) class and other patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta reported the highest score on PCS (83.6±17.2) and patients with isolated aortic valve disease had the highest QOL (82.0±13.8) (Fig 1). Patients with cyanotic heart disease or Eisenmenger syndrome showed the lowest scores both on PCS (53.5±21.8) and QOL (67.1±21.8). When taking the CHD with the highest score as reference, the PCS was significantly lower in patients with repaired ductus arteriosus/ASD/VSD, transposition of the great arteries, pulmonary atresia, Marfan, and cyanotic heart disease/Eisenmenger syndrome. For QOL, no differences were found for the types of CHD, when adjusted for other patient characteristics. Conclusions: Some types of CHD predict worse physical functioning, above and beyond NYHA class and other patient characteristics. CHD type was not found to be an independent predictor for QOL.

AB - Objectives: Higher complexity of congenital heart defects (CHD) is found to be associated with poorer physical functioning and quality of life (QOL). Within complexity categories, there may be a large variation in outcomes as well, according to the type of CHD. However, prior research is hampered by limited sample sizes. Therefore, we sought to compare the physical functioning and QOL in different CHD from a large international sample. Methods: In a cross-sectional study, we enrolled 4,028 adult CHD patients from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3,589 patients (median age=32y; 53% women). Physical functioning was measured using the Physical Component Summary (PCS) of the SF-12 (range 0-100). A linear analog scale was used to measure QOL, ranging from 0 (worst QOL) to 100 (best QOL). Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and physical functioning and QOL, adjusted for New York Heart Association (NYHA) class and other patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta reported the highest score on PCS (83.6±17.2) and patients with isolated aortic valve disease had the highest QOL (82.0±13.8) (Fig 1). Patients with cyanotic heart disease or Eisenmenger syndrome showed the lowest scores both on PCS (53.5±21.8) and QOL (67.1±21.8). When taking the CHD with the highest score as reference, the PCS was significantly lower in patients with repaired ductus arteriosus/ASD/VSD, transposition of the great arteries, pulmonary atresia, Marfan, and cyanotic heart disease/Eisenmenger syndrome. For QOL, no differences were found for the types of CHD, when adjusted for other patient characteristics. Conclusions: Some types of CHD predict worse physical functioning, above and beyond NYHA class and other patient characteristics. CHD type was not found to be an independent predictor for QOL.

UR - https://www.ahajournals.org/doi/10.1161/circ.140.suppl_1.16534

M3 - Article

JO - Circulation

JF - Circulation

ER -

Abstract 16534: Physical Functioning And Quality Of Life In Different Congenital Heart Defects: Comparative Analysis In 3,589 Patients From 15 Countries

Abstract

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