A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study

Cheryl R.Z. See; Shuqing Si; C. Lexi Baird; Courtney C. Haswell; Ahmed Hussain; Miranda Olff; Dick J. Veltman; Jessie L. Frijling; Mirjam Van Zuiden; Saskia B.J. Koch; Laura Nawijn; Li Wang; Ye Zhu; Gen Li; Yuval Neria; Xi Zhu; Benjamin Suarez-Jimenez; Sigal Zilcha-Mano; Amit Lazarov; Jennifer S. Stevens; Kerry Ressler; Negar Fani; Tanja Jovanovic; Sanne J.H. Van Rooij; Milissa L. Kaufman; Lauren A.M. Lebois; Isabelle M. Rosso; Elizabeth A. Olson; Justin T. Baker; Scott R. Sponheim; Seth G. Disner; Nicholas D. Davenport; Amit Etkin; Adi Maron-Katz; Murray B. Stein; Martha E. Shenton; Dan J. Stein; Jonathan Ipser; Sheri Michelle Koopowitz; Soraya Seedat; Stefan Du Plessis; Leigh L. Van Den Heuvel; Shmuel Lissek; Hannah Berg; Thomas Straube; David Hofman; Lee A. Baugh; Gina L. Forster; Raluca M. Simons; Jeffrey S. Simons; Vincent A. Magnotta; Kelene A. Fercho; Xin Wang; Andrew S. Cotton; Erin N. O'leary; Hong Xie; Daniel W. Grupe; Jack B. Nitschke; Richard J. Davidson; Christine L. Larson; Terri A. Deroon-Cassini; Carissa W. Tomas; Jacklynn M. Fitzgerald; Jennifer Urbano Blackford; Bunmi O. Olatunji; Evan M. Gordon; Geoffrey May; Steven M. Nelson; Ruth Lanius; Jean Théberge; Maria Densmore; Richard W.J. Neufeld; Chadi G. Abdallah; Christopher L. Averill; Ilan Harpaz-Rotem; Ifat Levy; John H. Krystal; Elbert Geuze; Remko Van Lutterveld; Emily L. Dennis; David F. Tate; David X. Cifu; William C. Walker; Elisabeth A. Wilde; Nic J.A. Van Der Wee; Robert R.J.M. Vermeiren; Steven J.A. Van Der Werff; Katie Mclaughlin; Kelly Sambrook; Matthew Peverill; Joaquim Radua; Lauren E. Salminen; Neda Jahanshad; Sophia I. Thomopoulos; Anthony James; Lucia Valmaggia; Paul M. Thompson; Rajendra A. Morey; Matthew J. Kempton

doi:10.1192/j.eurpsy.2025.10062

A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study

Cheryl R.Z. See, Shuqing Si, C. Lexi Baird, Courtney C. Haswell, Ahmed Hussain, Miranda Olff, Dick J. Veltman, Jessie L. Frijling, Mirjam Van Zuiden, Saskia B.J. Koch, Laura Nawijn, Li Wang, Ye Zhu, Gen Li, Yuval Neria, Xi Zhu, Benjamin Suarez-Jimenez, Sigal Zilcha-Mano, Amit Lazarov, Jennifer S. StevensKerry Ressler, Negar Fani, Tanja Jovanovic, Sanne J.H. Van Rooij, Milissa L. Kaufman, Lauren A.M. Lebois, Isabelle M. Rosso, Elizabeth A. Olson, Justin T. Baker, Scott R. Sponheim, Seth G. Disner, Nicholas D. Davenport, Amit Etkin, Adi Maron-Katz, Murray B. Stein, Martha E. Shenton, Dan J. Stein, Jonathan Ipser, Sheri Michelle Koopowitz, Soraya Seedat, Stefan Du Plessis, Leigh L. Van Den Heuvel, Shmuel Lissek, Hannah Berg, Thomas Straube, David Hofman, Lee A. Baugh, Gina L. Forster, Raluca M. Simons, Jeffrey S. Simons, Vincent A. Magnotta, Kelene A. Fercho, Xin Wang, Andrew S. Cotton, Erin N. O'leary, Hong Xie, Daniel W. Grupe, Jack B. Nitschke, Richard J. Davidson, Christine L. Larson, Terri A. Deroon-Cassini, Carissa W. Tomas, Jacklynn M. Fitzgerald, Jennifer Urbano Blackford, Bunmi O. Olatunji, Evan M. Gordon, Geoffrey May, Steven M. Nelson, Ruth Lanius, Jean Théberge, Maria Densmore, Richard W.J. Neufeld, Chadi G. Abdallah, Christopher L. Averill, Ilan Harpaz-Rotem, Ifat Levy, John H. Krystal, Elbert Geuze, Remko Van Lutterveld, Emily L. Dennis, David F. Tate, David X. Cifu, William C. Walker, Elisabeth A. Wilde, Nic J.A. Van Der Wee, Robert R.J.M. Vermeiren, Steven J.A. Van Der Werff, Katie Mclaughlin, Kelly Sambrook, Matthew Peverill, Joaquim Radua, Lauren E. Salminen, Neda Jahanshad, Sophia I. Thomopoulos, Anthony James, Lucia Valmaggia, Paul M. Thompson, Rajendra A. Morey, Matthew J. Kempton

Research output: Contribution to journal › Review article › peer-review

Original language	English
Article number	e97
Journal	European Psychiatry
Volume	68
Issue number	1
DOIs	https://doi.org/10.1192/j.eurpsy.2025.10062
State	Published - Jul 22 2025
Externally published	Yes

ASJC Scopus Subject Areas

Psychiatry and Mental health

Keywords

PTSD
brain structure
gray matter volume
neuroimaging
trauma
voxel-based morphometry

Access to Document

10.1192/j.eurpsy.2025.10062

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See, C. R. Z., Si, S., Baird, C. L., Haswell, C. C., Hussain, A., Olff, M., Veltman, D. J., Frijling, J. L., Van Zuiden, M., Koch, S. B. J., Nawijn, L., Wang, L., Zhu, Y., Li, G., Neria, Y., Zhu, X., Suarez-Jimenez, B., Zilcha-Mano, S., Lazarov, A., ... Kempton, M. J. (2025). A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study. European Psychiatry, 68(1), Article e97. https://doi.org/10.1192/j.eurpsy.2025.10062

See, CRZ, Si, S, Baird, CL, Haswell, CC, Hussain, A, Olff, M, Veltman, DJ, Frijling, JL, Van Zuiden, M, Koch, SBJ, Nawijn, L, Wang, L, Zhu, Y, Li, G, Neria, Y, Zhu, X, Suarez-Jimenez, B, Zilcha-Mano, S, Lazarov, A, Stevens, JS, Ressler, K, Fani, N, Jovanovic, T, Van Rooij, SJH, Kaufman, ML, Lebois, LAM, Rosso, IM, Olson, EA, Baker, JT, Sponheim, SR, Disner, SG, Davenport, ND, Etkin, A, Maron-Katz, A, Stein, MB, Shenton, ME, Stein, DJ, Ipser, J, Koopowitz, SM, Seedat, S, Du Plessis, S, Van Den Heuvel, LL, Lissek, S, Berg, H, Straube, T, Hofman, D, Baugh, LA, Forster, GL, Simons, RM, Simons, JS, Magnotta, VA, Fercho, KA, Wang, X, Cotton, AS, O'leary, EN, Xie, H, Grupe, DW, Nitschke, JB, Davidson, RJ, Larson, CL, Deroon-Cassini, TA, Tomas, CW, Fitzgerald, JM, Blackford, JU, Olatunji, BO, Gordon, EM, May, G, Nelson, SM, Lanius, R, Théberge, J, Densmore, M, Neufeld, RWJ, Abdallah, CG, Averill, CL, Harpaz-Rotem, I, Levy, I, Krystal, JH, Geuze, E, Van Lutterveld, R, Dennis, EL, Tate, DF, Cifu, DX, Walker, WC, Wilde, EA, Van Der Wee, NJA, Vermeiren, RRJM, Van Der Werff, SJA, Mclaughlin, K, Sambrook, K, Peverill, M, Radua, J, Salminen, LE, Jahanshad, N, Thomopoulos, SI, James, A, Valmaggia, L, Thompson, PM, Morey, RA & Kempton, MJ 2025, 'A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study', European Psychiatry, vol. 68, no. 1, e97. https://doi.org/10.1192/j.eurpsy.2025.10062

@article{a0fdd4594d5144ea8dc99ff78eddf53e,

title = "A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study",

keywords = "PTSD, brain structure, gray matter volume, neuroimaging, trauma, voxel-based morphometry",

author = "See, \{Cheryl R.Z.\} and Shuqing Si and Baird, \{C. Lexi\} and Haswell, \{Courtney C.\} and Ahmed Hussain and Miranda Olff and Veltman, \{Dick J.\} and Frijling, \{Jessie L.\} and \{Van Zuiden\}, Mirjam and Koch, \{Saskia B.J.\} and Laura Nawijn and Li Wang and Ye Zhu and Gen Li and Yuval Neria and Xi Zhu and Benjamin Suarez-Jimenez and Sigal Zilcha-Mano and Amit Lazarov and Stevens, \{Jennifer S.\} and Kerry Ressler and Negar Fani and Tanja Jovanovic and \{Van Rooij\}, \{Sanne J.H.\} and Kaufman, \{Milissa L.\} and Lebois, \{Lauren A.M.\} and Rosso, \{Isabelle M.\} and Olson, \{Elizabeth A.\} and Baker, \{Justin T.\} and Sponheim, \{Scott R.\} and Disner, \{Seth G.\} and Davenport, \{Nicholas D.\} and Amit Etkin and Adi Maron-Katz and Stein, \{Murray B.\} and Shenton, \{Martha E.\} and Stein, \{Dan J.\} and Jonathan Ipser and Koopowitz, \{Sheri Michelle\} and Soraya Seedat and \{Du Plessis\}, Stefan and \{Van Den Heuvel\}, \{Leigh L.\} and Shmuel Lissek and Hannah Berg and Thomas Straube and David Hofman and Baugh, \{Lee A.\} and Forster, \{Gina L.\} and Simons, \{Raluca M.\} and Simons, \{Jeffrey S.\} and Magnotta, \{Vincent A.\} and Fercho, \{Kelene A.\} and Xin Wang and Cotton, \{Andrew S.\} and O'leary, \{Erin N.\} and Hong Xie and Grupe, \{Daniel W.\} and Nitschke, \{Jack B.\} and Davidson, \{Richard J.\} and Larson, \{Christine L.\} and Deroon-Cassini, \{Terri A.\} and Tomas, \{Carissa W.\} and Fitzgerald, \{Jacklynn M.\} and Blackford, \{Jennifer Urbano\} and Olatunji, \{Bunmi O.\} and Gordon, \{Evan M.\} and Geoffrey May and Nelson, \{Steven M.\} and Ruth Lanius and Jean Th{\'e}berge and Maria Densmore and Neufeld, \{Richard W.J.\} and Abdallah, \{Chadi G.\} and Averill, \{Christopher L.\} and Ilan Harpaz-Rotem and Ifat Levy and Krystal, \{John H.\} and Elbert Geuze and \{Van Lutterveld\}, Remko and Dennis, \{Emily L.\} and Tate, \{David F.\} and Cifu, \{David X.\} and Walker, \{William C.\} and Wilde, \{Elisabeth A.\} and \{Van Der Wee\}, \{Nic J.A.\} and Vermeiren, \{Robert R.J.M.\} and \{Van Der Werff\}, \{Steven J.A.\} and Katie Mclaughlin and Kelly Sambrook and Matthew Peverill and Joaquim Radua and Salminen, \{Lauren E.\} and Neda Jahanshad and Thomopoulos, \{Sophia I.\} and Anthony James and Lucia Valmaggia and Thompson, \{Paul M.\} and Morey, \{Rajendra A.\} and Kempton, \{Matthew J.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Published by Cambridge University Press on behalf of European Psychiatric Association.",

year = "2025",

month = jul,

day = "22",

doi = "10.1192/j.eurpsy.2025.10062",

language = "English",

volume = "68",

journal = "European Psychiatry",

issn = "0924-9338",

number = "1",

}

TY - JOUR

T1 - A whole-brain voxel-based analysis of structural abnormalities in PTSD

T2 - An ENIGMA-PGC study

AU - See, Cheryl R.Z.

AU - Si, Shuqing

AU - Baird, C. Lexi

AU - Haswell, Courtney C.

AU - Hussain, Ahmed

AU - Olff, Miranda

AU - Veltman, Dick J.

AU - Frijling, Jessie L.

AU - Van Zuiden, Mirjam

AU - Koch, Saskia B.J.

AU - Nawijn, Laura

AU - Wang, Li

AU - Zhu, Ye

AU - Li, Gen

AU - Neria, Yuval

AU - Zhu, Xi

AU - Suarez-Jimenez, Benjamin

AU - Zilcha-Mano, Sigal

AU - Lazarov, Amit

AU - Stevens, Jennifer S.

AU - Ressler, Kerry

AU - Fani, Negar

AU - Jovanovic, Tanja

AU - Van Rooij, Sanne J.H.

AU - Kaufman, Milissa L.

AU - Lebois, Lauren A.M.

AU - Rosso, Isabelle M.

AU - Olson, Elizabeth A.

AU - Baker, Justin T.

AU - Sponheim, Scott R.

AU - Disner, Seth G.

AU - Davenport, Nicholas D.

AU - Etkin, Amit

AU - Maron-Katz, Adi

AU - Stein, Murray B.

AU - Shenton, Martha E.

AU - Stein, Dan J.

AU - Ipser, Jonathan

AU - Koopowitz, Sheri Michelle

AU - Seedat, Soraya

AU - Du Plessis, Stefan

AU - Van Den Heuvel, Leigh L.

AU - Lissek, Shmuel

AU - Berg, Hannah

AU - Straube, Thomas

AU - Hofman, David

AU - Baugh, Lee A.

AU - Forster, Gina L.

AU - Simons, Raluca M.

AU - Simons, Jeffrey S.

AU - Magnotta, Vincent A.

AU - Fercho, Kelene A.

AU - Wang, Xin

AU - Cotton, Andrew S.

AU - O'leary, Erin N.

AU - Xie, Hong

AU - Grupe, Daniel W.

AU - Nitschke, Jack B.

AU - Davidson, Richard J.

AU - Larson, Christine L.

AU - Deroon-Cassini, Terri A.

AU - Tomas, Carissa W.

AU - Fitzgerald, Jacklynn M.

AU - Blackford, Jennifer Urbano

AU - Olatunji, Bunmi O.

AU - Gordon, Evan M.

AU - May, Geoffrey

AU - Nelson, Steven M.

AU - Lanius, Ruth

AU - Théberge, Jean

AU - Densmore, Maria

AU - Neufeld, Richard W.J.

AU - Abdallah, Chadi G.

AU - Averill, Christopher L.

AU - Harpaz-Rotem, Ilan

AU - Levy, Ifat

AU - Krystal, John H.

AU - Geuze, Elbert

AU - Van Lutterveld, Remko

AU - Dennis, Emily L.

AU - Tate, David F.

AU - Cifu, David X.

AU - Walker, William C.

AU - Wilde, Elisabeth A.

AU - Van Der Wee, Nic J.A.

AU - Vermeiren, Robert R.J.M.

AU - Van Der Werff, Steven J.A.

AU - Mclaughlin, Katie

AU - Sambrook, Kelly

AU - Peverill, Matthew

AU - Radua, Joaquim

AU - Salminen, Lauren E.

AU - Jahanshad, Neda

AU - Thomopoulos, Sophia I.

AU - James, Anthony

AU - Valmaggia, Lucia

AU - Thompson, Paul M.

AU - Morey, Rajendra A.

AU - Kempton, Matthew J.

PY - 2025/7/22

Y1 - 2025/7/22

KW - PTSD

KW - brain structure

KW - gray matter volume

KW - neuroimaging

KW - trauma

KW - voxel-based morphometry

UR - https://www.scopus.com/pages/publications/105011382713

UR - https://www.scopus.com/inward/citedby.url?scp=105011382713&partnerID=8YFLogxK

U2 - 10.1192/j.eurpsy.2025.10062

DO - 10.1192/j.eurpsy.2025.10062

M3 - Review article

AN - SCOPUS:105011382713

SN - 0924-9338

VL - 68

JO - European Psychiatry

JF - European Psychiatry

IS - 1

M1 - e97

ER -

A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study

ASJC Scopus Subject Areas

Keywords

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