A Practical Gram-Scale Synthesis of Acrylohydroxamic Acid

Bruce C. Hamper; Brendan T. Sullivan; Nigam P. Rath; Christopher D. Spilling

doi:10.1055/s-0036-1589103

A Practical Gram-Scale Synthesis of Acrylohydroxamic Acid

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

Acrylohydroxamic acid, which is a useful monomer for the preparation of polymeric materials, has been prepared in a straightforward, two-step synthesis from readily available starting materials. The key steps are coupling of acrylic acid with O-tetrahydropyranylhydroxyl amine to provide protection of the hydroxylamine functionality, followed by acid cleavage of the protecting group.

Original language	American English
Journal	Synthesis
Volume	49
DOIs	https://doi.org/10.1055/s-0036-1589103
State	Published - Dec 1 2017

Disciplines

Organic Chemistry
Inorganic Chemistry

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title = "A Practical Gram-Scale Synthesis of Acrylohydroxamic Acid",

abstract = " Acrylohydroxamic acid, which is a useful monomer for the preparation of polymeric materials, has been prepared in a straightforward, two-step synthesis from readily available starting materials. The key steps are coupling of acrylic acid with O-tetrahydropyranylhydroxyl amine to provide protection of the hydroxylamine functionality, followed by acid cleavage of the protecting group.",

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AU - Spilling, Christopher D.

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AB - Acrylohydroxamic acid, which is a useful monomer for the preparation of polymeric materials, has been prepared in a straightforward, two-step synthesis from readily available starting materials. The key steps are coupling of acrylic acid with O-tetrahydropyranylhydroxyl amine to provide protection of the hydroxylamine functionality, followed by acid cleavage of the protecting group.

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VL - 49

JO - Synthesis

JF - Synthesis

ER -

A Practical Gram-Scale Synthesis of Acrylohydroxamic Acid

Abstract

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