Abstract
The preparation of (S)- and (R)-1-(dimethoxyphosphoryl)allyl methyl carbonates is achieved on multigram scale from commercially available dimethyl phosphite and acrolein in three steps. The key steps involve an asymmetric Pudovik reaction and enzyme-catalyzed kinetic resolution.
Original language | American English |
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Journal | Synthesis |
Volume | 47 |
DOIs | |
State | Published - Oct 21 2015 |
Disciplines
- Organic Chemistry