A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates

Sudeshna Roy, Nongnuch Sutivisedsak, Bruce C. Hamper, Alexander M. Lyss, Christopher D. Spilling

Research output: Contribution to journalArticlepeer-review

Abstract

The preparation of (S)- and (R)-1-(dimethoxyphosphoryl)allyl methyl carbonates is achieved on multigram scale from commercially available dimethyl phosphite and acrolein in three steps. The key steps involve an asymmetric Pudovik reaction and enzyme-catalyzed kinetic resolution.
Original languageAmerican English
JournalSynthesis
Volume47
DOIs
StatePublished - Oct 21 2015

Disciplines

  • Organic Chemistry

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