A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin

Dharmendra Neupane; Jay K. Bhattarai; Alexei V. Demchenko; Keith Stine

doi:10.1016/j.jddst.2020.101985

A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin

Dharmendra Neupane, Jay K. Bhattarai, Alexei V. Demchenko, Keith Stine

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Abstract

This article reports a novel thiolated β-cyclodextrin (HS-β-CD) modified nanoporous gold (NPG) wire for pH sensitive delivery of doxorubicin (DOX) in controlled manner. Nanoporous gold is a versatile material because of its three-dimensional nanoscale network of pores, facile surface functionalization, biocompatibility, and high capacity for the DOX payload. HS-β-CD can form supramolecular inclusion complexes with DOX affording the possibility of altering the controlled release behavior. DOX is one of the most potent anti-tumor drugs used in the treatment of different cancers. The binding of HS-β-CD and DOX was examined using UV–Vis spectroscopy. The prepared NPG structure exhibited excellent properties for controlled drug release outlining the potential of a pH sensitive drug implant for biomedical applications. This delivery system could improve local targeting of the drug as well as alter the rate of release of DOX near tumors.

Original language	American English
Journal	Journal of Drug Delivery Science and Technology
Volume	60
DOIs	https://doi.org/10.1016/j.jddst.2020.101985
State	Published - Dec 2020

Keywords

Nanoporous gold
Doxorubicin
Cyclodextrin
Drug release

Disciplines

Biochemistry, Biophysics, and Structural Biology
Biochemistry

Access to Document

10.1016/j.jddst.2020.101985License: Unspecified

Cite this

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title = "A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin",

abstract = " This article reports a novel thiolated β-cyclodextrin (HS-β-CD) modified nanoporous gold (NPG) wire for pH sensitive delivery of doxorubicin (DOX) in controlled manner. Nanoporous gold is a versatile material because of its three-dimensional nanoscale network of pores, facile surface functionalization, biocompatibility, and high capacity for the DOX payload. HS-β-CD can form supramolecular inclusion complexes with DOX affording the possibility of altering the controlled release behavior. DOX is one of the most potent anti-tumor drugs used in the treatment of different cancers. The binding of HS-β-CD and DOX was examined using UV–Vis spectroscopy. The prepared NPG structure exhibited excellent properties for controlled drug release outlining the potential of a pH sensitive drug implant for biomedical applications. This delivery system could improve local targeting of the drug as well as alter the rate of release of DOX near tumors. ",

keywords = "Nanoporous gold, Doxorubicin, Cyclodextrin, Drug release",

author = "Dharmendra Neupane and Bhattarai, {Jay K.} and Demchenko, {Alexei V.} and Keith Stine",

year = "2020",

month = dec,

doi = "10.1016/j.jddst.2020.101985",

language = "American English",

volume = "60",

journal = "Journal of Drug Delivery Science and Technology",

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T1 - A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin

AU - Neupane, Dharmendra

AU - Bhattarai, Jay K.

AU - Demchenko, Alexei V.

AU - Stine, Keith

PY - 2020/12

Y1 - 2020/12

N2 - This article reports a novel thiolated β-cyclodextrin (HS-β-CD) modified nanoporous gold (NPG) wire for pH sensitive delivery of doxorubicin (DOX) in controlled manner. Nanoporous gold is a versatile material because of its three-dimensional nanoscale network of pores, facile surface functionalization, biocompatibility, and high capacity for the DOX payload. HS-β-CD can form supramolecular inclusion complexes with DOX affording the possibility of altering the controlled release behavior. DOX is one of the most potent anti-tumor drugs used in the treatment of different cancers. The binding of HS-β-CD and DOX was examined using UV–Vis spectroscopy. The prepared NPG structure exhibited excellent properties for controlled drug release outlining the potential of a pH sensitive drug implant for biomedical applications. This delivery system could improve local targeting of the drug as well as alter the rate of release of DOX near tumors.

AB - This article reports a novel thiolated β-cyclodextrin (HS-β-CD) modified nanoporous gold (NPG) wire for pH sensitive delivery of doxorubicin (DOX) in controlled manner. Nanoporous gold is a versatile material because of its three-dimensional nanoscale network of pores, facile surface functionalization, biocompatibility, and high capacity for the DOX payload. HS-β-CD can form supramolecular inclusion complexes with DOX affording the possibility of altering the controlled release behavior. DOX is one of the most potent anti-tumor drugs used in the treatment of different cancers. The binding of HS-β-CD and DOX was examined using UV–Vis spectroscopy. The prepared NPG structure exhibited excellent properties for controlled drug release outlining the potential of a pH sensitive drug implant for biomedical applications. This delivery system could improve local targeting of the drug as well as alter the rate of release of DOX near tumors.

KW - Nanoporous gold

KW - Doxorubicin

KW - Cyclodextrin

KW - Drug release

UR - http://doi.org/10.1016/J.JDDST.2020.101985

UR - https://doi.org/10.1016/J.JDDST.2020.101985

U2 - 10.1016/j.jddst.2020.101985

DO - 10.1016/j.jddst.2020.101985

M3 - Article

VL - 60

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

ER -

A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin

Abstract

Keywords

Disciplines

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