β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

Beibei Liu; Shuo Wang; Karl Aston; Kevin J. Koeller; Shahrzad Fanny Hakami Kermani; Carlos H. Castañeda; M. José Scuderi; Rensheng Luo; James K. Bashkin; W. David Wilson

doi:10.1039/C7OB02513K

β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

Beibei Liu
, Shuo Wang
, Karl Aston
, Kevin J. Koeller
, Shahrzad Fanny Hakami Kermani
, Carlos H. Castañeda
, M. José Scuderi
, Rensheng Luo
, James K. Bashkin
, W. David Wilson

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Organic and Biomolecular Chemistry
Volume	15
DOIs	https://doi.org/10.1039/C7OB02513K
State	Published - Jan 1 2017

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Biochemistry
Organic Chemistry

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@article{eda0487cda424d47b2d673f2548c1513,

title = "β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding",

author = "Beibei Liu and Shuo Wang and Karl Aston and Koeller, \{Kevin J.\} and Kermani, \{Shahrzad Fanny Hakami\} and Casta{\~n}eda, \{Carlos H.\} and Scuderi, \{M. Jos{\'e}\} and Rensheng Luo and Bashkin, \{James K.\} and Wilson, \{W. David\}",

note = "Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible modules, such as β-alanine (β) motifs to replace pyrroles (Py), and increasing compound charge using N-terminal cationic substituents. To better understa Chemical biology in OBC",

year = "2017",

month = jan,

day = "1",

doi = "10.1039/C7OB02513K",

language = "American English",

volume = "15",

journal = "Organic and Biomolecular Chemistry",

}

TY - JOUR

T1 - β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

AU - Liu, Beibei

AU - Wang, Shuo

AU - Aston, Karl

AU - Koeller, Kevin J.

AU - Kermani, Shahrzad Fanny Hakami

AU - Castañeda, Carlos H.

AU - Scuderi, M. José

AU - Luo, Rensheng

AU - Bashkin, James K.

AU - Wilson, W. David

N1 - Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible modules, such as β-alanine (β) motifs to replace pyrroles (Py), and increasing compound charge using N-terminal cationic substituents. To better understa Chemical biology in OBC

PY - 2017/1/1

Y1 - 2017/1/1

UR - https://pubs.rsc.org/en/content/articlelanding/2017/ob/c7ob02513k

U2 - 10.1039/C7OB02513K

DO - 10.1039/C7OB02513K

M3 - Article

VL - 15

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

ER -

β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

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