β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

Beibei Liu; Shuo Wang; Karl Aston; Kevin J. Koeller; Shahrzad Fanny Hakami Kermani; Carlos H. Castañeda; M. José Scuderi; Rensheng Luo; James K. Bashkin; W. David Wilson

doi:10.1039/C7OB02513K

β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

Beibei Liu, Shuo Wang, Karl Aston, Kevin J. Koeller, Shahrzad Fanny Hakami Kermani, Carlos H. Castañeda, M. José Scuderi, Rensheng Luo, James K. Bashkin, W. David Wilson

University of Missouri-St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Organic and Biomolecular Chemistry
Volume	15
DOIs	https://doi.org/10.1039/C7OB02513K
State	Published - Jan 1 2017

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Biochemistry
Organic Chemistry

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@article{eda0487cda424d47b2d673f2548c1513,

title = "β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding",

author = "Beibei Liu and Shuo Wang and Karl Aston and Koeller, {Kevin J.} and Kermani, {Shahrzad Fanny Hakami} and Casta{\~n}eda, {Carlos H.} and Scuderi, {M. Jos{\'e}} and Rensheng Luo and Bashkin, {James K.} and Wilson, {W. David}",

note = "Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible modules, such as β-alanine (β) motifs to replace pyrroles (Py), and increasing compound charge using N-terminal cationic substituents. To better understa Chemical biology in OBC",

year = "2017",

month = jan,

day = "1",

doi = "10.1039/C7OB02513K",

language = "American English",

volume = "15",

journal = "Organic and Biomolecular Chemistry",

}

TY - JOUR

T1 - β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

AU - Liu, Beibei

AU - Wang, Shuo

AU - Aston, Karl

AU - Koeller, Kevin J.

AU - Kermani, Shahrzad Fanny Hakami

AU - Castañeda, Carlos H.

AU - Scuderi, M. José

AU - Luo, Rensheng

AU - Bashkin, James K.

AU - Wilson, W. David

N1 - Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible modules, such as β-alanine (β) motifs to replace pyrroles (Py), and increasing compound charge using N-terminal cationic substituents. To better understa Chemical biology in OBC

PY - 2017/1/1

Y1 - 2017/1/1

UR - https://pubs.rsc.org/en/content/articlelanding/2017/ob/c7ob02513k

U2 - 10.1039/C7OB02513K

DO - 10.1039/C7OB02513K

M3 - Article

VL - 15

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

ER -

β-Alanine and N-Terminal Cationic Substituents Affect Polyamide–DNA Binding

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